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Cycloleucine

CAT: 0013-GTR19216356-02Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19216356-02Size:25 mg
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Description
Cycloleucine is an antagonist of NMDA receptor associated glycine receptor with a Ki of 600 μM. Cycloleucine is also a competitive inhibitor of S-adenosyl-methionine mediated methylation with anxiolytic and cytostatic effects. (In Vitro) :Cytostatic (10 μg/mL) inhibits the viability of human KB and mouse L1210s leukemia cell lines. Cycloleucine (4-40 mM; 3 h) blocks internal methylation of viral RNA in B77 transformed chick embryo fibroblasts. Cycloleucine (40 mM; 24 h) blocks the formation of both m6A and the penultimate Gm in B77 38S RNA subunits by greater than 90%. (In Vivo) :Cycloleucine (0.5, 1.0, 2.0, 4 μg/μL; intracerebroventrically) increases time spent in open arms, open arm entries, and extreme arrivals in rats. In Semliki Forest virus strain A7 (74) infected and control mice, Cycloleucine reduces thymus and spleen weights.
CAS Number
52-52-8
Purity
>98% (HPLC)
Solubility
In Vitro: H2O : 20 mg/mL (154.85 mM)
Smiles
NC1 (CCCC1) C (O) =O
Molecular Formula
C6H11NO2
Molecular Weight
129.159
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.

Chemical Information

Cycloleucine

1-aminocyclopentanecarboxylic acid is a non-proteinogenic alpha-amino acid that is cyclopentane substituted at position 1 by amino and carboxy groups. It has a role as an EC 2.5.1.6 (methionine adenosyltransferase) inhibitor.

CAS Number52-52-8
PubChem CID2901
IUPAC Name1-aminocyclopentane-1-carboxylic acid
Molecular FormulaC6H11NO2
Molecular Weight129.16
XLogP-2.6
Topological Polar Surface Area63.3
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count3
Rotatable Bond Count1
Heavy Atom Count9
Formal Charge0
Complexity127
SMILES
C1CCC(C1)(C(=O)O)N
InChI
InChI=1S/C6H11NO2/c7-6(5(8)9)3-1-2-4-6/h1-4,7H2,(H,8,9)
InChIKey
NILQLFBWTXNUOE-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Cycloleucine
CAS: 52-52-8
CID: 2901
Formula: C6H11NO2
MW: 129.16
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight129.16
XLogP3-2.6
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count3
Rotatable Bond Count1
Exact Mass129.078978594
Monoisotopic Mass129.078978594
Topological Polar Surface Area63.3 Ų
Heavy Atom Count9
Formal Charge0
Complexity127
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
MBS3617325-01Cycloleucine
265328-01Boc-cycloleucine
C32057-01Cycloleucine 97%
TYD-03196-01Cycloleucine-CoA
450447-01Fmoc-Cycloleucine

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