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Cycloleucine

CAT: 0804-HY-30008Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-30008Size:25 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Cycloleucine is a specific inhibitor of S-adenosyl-methionine mediated methylation. Cycloleucine is antagonist of NMDA receptor associated glycine receptor, with a Ki of 600 μM. Cycloleucine is also a competitive inhibitor of ATP: L-methionine-S-adenosyl transferase in vitro. Cycloleucine has anxiolytic and cytostatic effects[1][2][3][4].
CAS Number
52-52-8
UNSPSC
12352211
Hazard Statement
H301
Target
IGluR
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Cancer; Infection; Metabolic Disease; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/cycloleucine.html
Purity
98.0
Solubility
DMSO : < 1 mg/mL (ultrasonic) |H2O : 20 mg/mL (ultrasonic)
Smiles
O=C(O)C1(CCCC1)N
Molecular Formula
C6H11NO2
Molecular Weight
129.16
Precautions
H301
References & Citations
[1]Hood WF, et, al. 1-Aminocyclobutane-1-carboxylate (ACBC) : a specific antagonist of the N-methyl-D-aspartate receptor coupled glycine receptor. Eur J Pharmacol. 1989 Feb 28;161 (2-3) :281-2.|[2]Caboche M, et, al. RNA methylation and control of eukaryotic RNA biosynthesis. Effects of cycloleucine, a specific inhibitor of methylation, on ribosomal RNA maturation. Eur J Biochem. 1977 Mar 15;74 (1) :19-29.|[3]Gargiulo API, et, al. Effects of Cycloleucine in the Nucleus Accumbens Septi on the Elevated plus Maze Test in Rats. Neuropsychobiology. 2020;79 (3) :191-197.|[4]Dimock K, et, al. Cycloleucine blocks 5'-terminal and internal methylations of avian sarcoma virus genome RNA. Biochemistry. 1978 Aug 22;17 (17) :3627-32.|[5]Duś D, et, al. Cytostatic activity in vitro of cycloleucine, aspartic acid and glutamic acid phosphonic analogues. Arch Immunol Ther Exp (Warsz) . 1980;28 (3) :433-8.|[6]S Amor, et al. The effect of cycloleucine on SFV A7 (74) infection in mice. Br J Exp Pathol. 1987 Apr;68 (2) :225-35.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
NMDA Receptor

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