Cycloleucine

• Description :

  Cycloleucine is a specific inhibitor of S-adenosyl-methionine mediated methylation. Cycloleucine is antagonist of NMDA receptor associated glycine receptor, with a Ki of 600 μM. Cycloleucine is also a competitive inhibitor of ATP: L-methionine-S-adenosyl transferase in vitro. Cycloleucine has anxiolytic and cytostatic effects[1][2][3][4].

• UNSPSC :

  12352211

• Hazard Statement :

  H301

• Target :

  IGluR

• Type :

  Reference compound

• Related Pathways :

  Membrane Transporter/Ion Channel; Neuronal Signaling

• Applications :

  Metabolism-protein/nucleotide metabolism

• Field of Research :

  Cancer; Infection; Metabolic Disease; Neurological Disease

• Assay Protocol :

  https://www.medchemexpress.com/cycloleucine.html

• Purity :

  98.0

• Solubility :

  DMSO : < 1 mg/mL (ultrasonic) |H2O : 20 mg/mL (ultrasonic)

• Smiles :

  O=C(O)C1(CCCC1)N

• Molecular Formula :

  C6H11NO2

• Molecular Weight :

  129.16

• Precautions :

  H301

• References & Citations :

  [1]Hood WF, et, al. 1-Aminocyclobutane-1-carboxylate (ACBC) : a specific antagonist of the N-methyl-D-aspartate receptor coupled glycine receptor. Eur J Pharmacol. 1989 Feb 28;161 (2-3) :281-2.|[2]Caboche M, et, al. RNA methylation and control of eukaryotic RNA biosynthesis. Effects of cycloleucine, a specific inhibitor of methylation, on ribosomal RNA maturation. Eur J Biochem. 1977 Mar 15;74 (1) :19-29.|[3]Gargiulo API, et, al. Effects of Cycloleucine in the Nucleus Accumbens Septi on the Elevated plus Maze Test in Rats. Neuropsychobiology. 2020;79 (3) :191-197.|[4]Dimock K, et, al. Cycloleucine blocks 5'-terminal and internal methylations of avian sarcoma virus genome RNA. Biochemistry. 1978 Aug 22;17 (17) :3627-32.|[5]Duś D, et, al. Cytostatic activity in vitro of cycloleucine, aspartic acid and glutamic acid phosphonic analogues. Arch Immunol Ther Exp (Warsz) . 1980;28 (3) :433-8.|[6]S Amor, et al. The effect of cycloleucine on SFV A7 (74) infection in mice. Br J Exp Pathol. 1987 Apr;68 (2) :225-35.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  NMDA Receptor

• CAS Number :

  [52-52-8]