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2'-Fluoro-2'-Deoxyadenosine

CAT: 0013-GTR19216347-01Size: 200 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19216347-01Size:200 mg
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Description
2'-Fluoro-2'-Deoxyadenosine is efficiently cleaved to the toxic 2-fluoroadenine (FAde) by Escherichia coli purine nucleoside phosphorylase (PNP) . 2'-Fluoro-2'-Deoxyadenosine showed good in vivo activity against tumors expressing E. coli PNP. 2'-Fluoro-2'-Deoxyadenosine can be used to synthesize 2'-deoxy-2'-fluoromodified oligonucleotides that can hybridize to RNA.
CAS Number
64183-27-3
Purity
>98% (HPLC)
Solubility
In Vitro: DMSO : 50 mg/mL (185.71 mM)
Smiles
Nc1ncnc2n (cnc12) [C@@H]1O[C@H] (CO) [C@@H] (O) [C@H]1F
Molecular Formula
C10H12FN5O3
Molecular Weight
269.236
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.

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