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(S) - (-) -Bay-K-8644

CAT: 0013-GTR19216218-01Size: 100 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19216218-01Size:100 mg
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Description
(S) - (-) -Bay-K-8644 is an agonist of L-type Ca2+ channel and activates Ba2+ currents with an EC50 of 32 nM. (In Vitro) :The Ca2+ channel activity is enhanced by 3–30 μM (S) - (-) -Bay-K-8644 an agonist of L-type Ca2+ channels . FPL 64176 (300 nM) causes a sustained contraction of rat tail artery strips. This contractile response is inhibited by approximately 70% by (S) - (-) -Bay-K-8644 (EC50: 14 nM) . (S) - (-) -Bay-K-8644 (100 nM) increases whole-cell Ca2+ currents in A7r5 smooth muscle cells but effectively blocks further stimulation by 1 μM FPL 64176 . (S) - (-) -Bay-K-8644 can prevent the inhibitory actions of two distinct cyclic nucleotide pathways on IBa in gastric myocytes of the guinea pig antrum.
CAS Number
98625-26-4
Product Name Alternative
(S) - (-) -Bay K 8644
Purity
>98% (HPLC)
Solubility
In Vitro: DMSO : 100 mg/mL (280.66 mM)
Smiles
COC (=O) C1=C (C) NC (C) =C ([C@H]1c1ccccc1C (F) (F) F) [N+] ([O-]) =O
Molecular Formula
C16H15F3N2O4
Molecular Weight
356.301
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.

Chemical Information

S(-)-Bay k 8644

(S)-Bay-K-8644 is a methyl 2,6-dimethyl-5-nitro-4-[2-(trifluoromethyl)phenyl]-1,4-dihydropyridine-3-carboxylate in which the 4-position has (S)-configuration. It is an enantiomer of a (R)-Bay-K-8644.

CAS Number98625-26-4
PubChem CID6603728
IUPAC Namemethyl (4S)-2,6-dimethyl-5-nitro-4-[2-(trifluoromethyl)phenyl]-1,4-dihydropyridine-3-carboxylate
Molecular FormulaC16H15F3N2O4
Molecular Weight356.30
XLogP3.4
Topological Polar Surface Area84.2
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count8
Rotatable Bond Count3
Heavy Atom Count25
Formal Charge0
Complexity634
SMILES
CC1=C([C@@H](C(=C(N1)C)[N+](=O)[O-])C2=CC=CC=C2C(F)(F)F)C(=O)OC
InChI
InChI=1S/C16H15F3N2O4/c1-8-12(15(22)25-3)13(14(21(23)24)9(2)20-8)10-6-4-5-7-11(10)16(17,18)19/h4-7,13,20H,1-3H3/t13-/m0/s1
InChIKey
ZFLWDHHVRRZMEI-ZDUSSCGKSA-N
Chemical Structure
2D Structure
2D structure of S(-)-Bay k 8644
CAS: 98625-26-4
CID: 6603728
Formula: C16H15F3N2O4
MW: 356.30
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight356.30
XLogP33.4
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count8
Rotatable Bond Count3
Exact Mass356.09839145
Monoisotopic Mass356.09839145
Topological Polar Surface Area84.2 Ų
Heavy Atom Count25
Formal Charge0
Complexity634
Isotope Atom Count0
Defined Atom Stereocenter Count1
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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