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Foldamer 33

CAT: 0013-GTR19216140Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19216140Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Foldamer 33 is a small molecule HSP110 inhibitor, directly binds to the nucleotide-binding domain (NBD) of HSP110, blocks HSP110 chaperone function and colorectal cancer growth.Foldamer 33 significantly inhibit HSP110 anti-aggregating activity with IC50 of 87.8 uM.Foldamer 33 disrupts HSP110-STAT3 interaction with IC50 of 35.9 uM in competitive BLI assays.Foldamer 33 inhibits SW480 colorectal cancer cell proliferation, and (5 mg/kg) Foldamer 33 displays an anti-tumor effect (TGI of 40% and 60%) in mice bearing a colorectal cancer.
CAS Number
1651890-48-0
Purity
0.98
Molecular Formula
C36H34N2O5
Molecular Weight
574.677
Notes
For research use only.

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