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Mal-PEG4-NHS ester

CAT: 0013-GTR19215778-01Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19215778-01Size:25 mg
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Description
This product is a non-cleavable ADC linker featuring a maleimide group for thiol conjugation, a tetraethylene glycol (PEG4) spacer, and an NHS ester for amine coupling. It is widely used in bioconjugation for constructing stable antibody-drug conjugates (ADCs) for both in vitro and in vivo therapeutic research.
CAS Number
1325208-25-0
Product Name Alternative
Mal-PEG4-NHS ester, Mal​PEG4​NHS ester, Mal-​PEG-4-​NHS ester, Mal ​PEG4 ​NHS ester, Non-cleavable, ADCLinker, ADC Linker
Field of Research
Pharmacology & Drug Discovery
Purity
98.31% (May vary between batches)
Solubility
DMSO:80 mg/mL (180.82 mM) ;10% DMSO+90% Corn Oil:3.3 mg/mL (7.46 mM)
Smiles
O=C (ON1C (=O) CCC1=O) CCOCCOCCOCCOCCN2C (=O) C=CC2=O
Molecular Formula
C19H26N2O10
Molecular Weight
442.42
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

Mal-PEG4-NHS ester
CAS Number1325208-25-0
PubChem CID60146183
IUPAC Name(2,5-dioxopyrrolidin-1-yl) 3-[2-[2-[2-[2-(2,5-dioxopyrrol-1-yl)ethoxy]ethoxy]ethoxy]ethoxy]propanoate
Molecular FormulaC19H26N2O10
Molecular Weight442.4
XLogP-2.2
Topological Polar Surface Area138
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count10
Rotatable Bond Count17
Heavy Atom Count31
Formal Charge0
Complexity659
SMILES
C1CC(=O)N(C1=O)OC(=O)CCOCCOCCOCCOCCN2C(=O)C=CC2=O
InChI
InChI=1S/C19H26N2O10/c22-15-1-2-16(23)20(15)6-8-28-10-12-30-14-13-29-11-9-27-7-5-19(26)31-21-17(24)3-4-18(21)25/h1-2H,3-14H2
InChIKey
TUPOSLKVPPFQGR-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Mal-PEG4-NHS ester
CAS: 1325208-25-0
CID: 60146183
Formula: C19H26N2O10
MW: 442.4
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight442.4
XLogP3-2.2
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count10
Rotatable Bond Count17
Exact Mass442.15874503
Monoisotopic Mass442.15874503
Topological Polar Surface Area138 Ų
Heavy Atom Count31
Formal Charge0
Complexity659
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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