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FL118

CAT: 0013-GTR19213773-06Size: 100 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19213773-06Size:100 mg
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Description
FL118 is a novel camptothecin analog that acts as a survivin inhibitor, suppressing cancer stem cell-like properties. It inhibits epithelial-mesenchymal transition, migration, and invasion in breast cancer cells by targeting the Wnt/β-catenin pathway, as demonstrated in in vitro studies.
CAS Number
135415-73-5
Product Name Alternative
10,11- (Methylenedioxy) -20 (S) -camptothecin, 10,11- (Methylenedioxy) -20camptothecin, FL 118, FL118, FL-118, Survivin
Field of Research
Cell Biology
Purity
97.14% (May vary between batches)
Solubility
DMSO:2 mg/mL (5.1 mM)
Smiles
C (C) [C@]1 (O) C2=C (C (=O) N3C (=C2) C=4C (C3) =CC=5C (N4) =CC6=C (C5) OCO6) COC1=O
Molecular Formula
C21H16N2O6
Molecular Weight
392.36
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

10,11-Methylenedioxy-20-camptothecin

structure given in first source

CAS Number135415-73-5
PubChem CID72403
IUPAC Name(5S)-5-ethyl-5-hydroxy-7,18,20-trioxa-11,24-diazahexacyclo[11.11.0.02,11.04,9.015,23.017,21]tetracosa-1(13),2,4(9),14,16,21,23-heptaene-6,10-dione
Molecular FormulaC21H16N2O6
Molecular Weight392.4
XLogP0.8
Topological Polar Surface Area98.2
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count7
Rotatable Bond Count1
Heavy Atom Count29
Formal Charge0
Complexity852
SMILES
CC[C@@]1(C2=C(COC1=O)C(=O)N3CC4=C(C3=C2)N=C5C=C6C(=CC5=C4)OCO6)O
InChI
InChI=1S/C21H16N2O6/c1-2-21(26)13-5-15-18-11(7-23(15)19(24)12(13)8-27-20(21)25)3-10-4-16-17(29-9-28-16)6-14(10)22-18/h3-6,26H,2,7-9H2,1H3/t21-/m0/s1
InChIKey
RPFYDENHBPRCTN-NRFANRHFSA-N
Chemical Structure
2D Structure
2D structure of 10,11-Methylenedioxy-20-camptothecin
CAS: 135415-73-5
CID: 72403
Formula: C21H16N2O6
MW: 392.4
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight392.4
XLogP30.8
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count7
Rotatable Bond Count1
Exact Mass392.10083623
Monoisotopic Mass392.10083623
Topological Polar Surface Area98.2 Ų
Heavy Atom Count29
Formal Charge0
Complexity852
Isotope Atom Count0
Defined Atom Stereocenter Count1
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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