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DpC

CAT: 0013-GTR19214534-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19214534-01Size:1 mg
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Description
DPC is a potent small molecule anticancer agent that inhibits cell proliferation with low micromolar IC50 values. It has demonstrated activity in both in vitro and in vivo cancer models, making it a useful tool for investigating oncology-related pathways and therapeutic strategies.
CAS Number
1382469-39-7
Purity
97.14% (May vary between batches)
Solubility
DMSO:50 mg/mL (141.45 mM) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (5.66 mM)
Smiles
C (=NNC (N (C) C1CCCCC1) =S) (C2=CC=CC=N2) C3=CC=CC=N3
Molecular Formula
C19H23N5S
Molecular Weight
353.48
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

Di-2-pyridylketone 4-cyclohexyl-4-methyl-3-thiosemicarbazone

Di-2-pyridylketone 4-cyclohexyl-4-methyl-3-thiosemicarbazone is under investigation in clinical trial NCT02688101 (Dose-finding and Pharmacokinetic Study of DpC, Administered Orally to Patients With Advanced Solid Tumors).

CAS Number1382469-39-7
PubChem CID57380301
IUPAC Name1-cyclohexyl-3-(dipyridin-2-ylmethylideneamino)-1-methylthiourea
Molecular FormulaC19H23N5S
Molecular Weight353.5
XLogP4
Topological Polar Surface Area85.5
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count4
Rotatable Bond Count4
Heavy Atom Count25
Formal Charge0
Complexity441
SMILES
CN(C1CCCCC1)C(=S)NN=C(C2=CC=CC=N2)C3=CC=CC=N3
InChI
InChI=1S/C19H23N5S/c1-24(15-9-3-2-4-10-15)19(25)23-22-18(16-11-5-7-13-20-16)17-12-6-8-14-21-17/h5-8,11-15H,2-4,9-10H2,1H3,(H,23,25)
InChIKey
GNLZNQJBZNOUBM-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Di-2-pyridylketone 4-cyclohexyl-4-methyl-3-thiosemicarbazone
CAS: 1382469-39-7
CID: 57380301
Formula: C19H23N5S
MW: 353.5
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight353.5
XLogP34
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count4
Rotatable Bond Count4
Exact Mass353.16741693
Monoisotopic Mass353.16741693
Topological Polar Surface Area85.5 Ų
Heavy Atom Count25
Formal Charge0
Complexity441
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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