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Xanthone

CAT: 0804-HY-N0126-01Size: 1 gDry Ice: NoHazardous: No
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CAT#:0804-HY-N0126-01Size:1 g
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Description
Xanthone is a monoamine oxidase A (MAO-A) inhibitor with an IC50 of 0.84 µM. Xanthon inhibits Norepinephrine and high-K+-induced vasoconstriction with IC50 values of 60.26 μM and 82.9 μM, respectively. Xanthon increases intracellular cyclic adenosine 3′,5′-monophosphate (cAMP) content and blocks Ca2+ channels. Xanthone is the scaffold of several pharmacologically active compounds[1][2].
CAS Number
90-47-1
UNSPSC
12352005
Hazard Statement
H410
Target
Calcium Channel; Monoamine Oxidase
Type
Natural Products
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Cancer-programmed cell death
Field of Research
Neurological Disease; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/xanthone.html
Concentration
10mM
Purity
99.97
Solubility
DMSO : 10 mg/mL (ultrasonic)
Smiles
O=C1C2=C(OC3=C1C=CC=C3)C=CC=C2
Molecular Formula
C13H8O2
Molecular Weight
196.21
Precautions
H410
References & Citations
[1]Cheng YW, et al. Mechanism of vasorelaxation of thoracic aorta caused by xanthone. Eur J Pharmacol. 1997 Oct 1;336 (1) :23-8. |[2]El-Seedi HR, et al. Recent insights into the biosynthesis and biological activities of natural xanthones. Curr Med Chem. 2010;17 (9) :854-901.
Shipping Conditions
Room Temperature
Storage Conditions
Store at room temperature 3 years
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
MAO-A

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