Xanthone

• Description:

  Xanthone is a monoamine oxidase A (MAO-A) inhibitor with an IC50 of 0.84 µM. Xanthon inhibits Norepinephrine (HY-13715) and high-K+-induced vasoconstriction with IC50 values of 60.26 μM and 82.9 μM, respectively. Xanthon increases intracellular cyclic adenosine 3′,5′-monophosphate (cAMP) content and blocks Ca2+ channels. Xanthone is the scaffold of several pharmacologically active compounds[1][2].

• UNSPSC:

  12352005

• Hazard Statement:

  H410

• Target:

  Calcium Channel; Monoamine Oxidase

• Type:

  Natural Products

• Related Pathways:

  Membrane Transporter/Ion Channel; Neuronal Signaling

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Neurological Disease; Cardiovascular Disease

• Assay Protocol:

  https://www.medchemexpress.com/xanthone.html

• Concentration:

  10mM

• Purity:

  99.97

• Solubility:

  DMSO : 10 mg/mL (ultrasonic)

• Smiles:

  O=C1C2=C (OC3=C1C=CC=C3) C=CC=C2

• Molecular Formula:

  C13H8O2

• Molecular Weight:

  196.21

• Precautions:

  H410

• References & Citations:

  [1]Cheng YW, et al. Mechanism of vasorelaxation of thoracic aorta caused by xanthone. Eur J Pharmacol. 1997 Oct 1;336 (1) :23-8. |[2]El-Seedi HR, et al. Recent insights into the biosynthesis and biological activities of natural xanthones. Curr Med Chem. 2010;17 (9) :854-901.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  Store at room temperature 3 years

• Scientific Category:

  Natural Products

• Clinical Information:

  No Development Reported

• Isoform:

  MAO-A

• CAS Number:

  90-47-1