Xanthone

• Description :

  Xanthone is a monoamine oxidase A (MAO-A) inhibitor with an IC50 of 0.84 µM. Xanthon inhibits Norepinephrine (HY-13715) and high-K+-induced vasoconstriction with IC50 values of 60.26 μM and 82.9 μM, respectively. Xanthon increases intracellular cyclic adenosine 3′,5′-monophosphate (cAMP) content and blocks Ca2+ channels. Xanthone is the scaffold of several pharmacologically active compounds[1][2].

• UNSPSC :

  12352005

• Hazard Statement :

  H410

• Target :

  Calcium Channel; Monoamine Oxidase

• Type :

  Natural Products

• Related Pathways :

  Membrane Transporter/Ion Channel; Neuronal Signaling

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Neurological Disease; Cardiovascular Disease

• Assay Protocol :

  https://www.medchemexpress.com/xanthone.html

• Concentration :

  10mM

• Purity :

  99.97

• Solubility :

  DMSO : 10 mg/mL (ultrasonic)

• Smiles :

  O=C1C2=C(OC3=C1C=CC=C3)C=CC=C2

• Molecular Formula :

  C13H8O2

• Molecular Weight :

  196.21

• Precautions :

  H410

• References & Citations :

  [1]Cheng YW, et al. Mechanism of vasorelaxation of thoracic aorta caused by xanthone. Eur J Pharmacol. 1997 Oct 1;336 (1) :23-8. |[2]El-Seedi HR, et al. Recent insights into the biosynthesis and biological activities of natural xanthones. Curr Med Chem. 2010;17 (9) :854-901.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  Store at room temperature 3 years

• Scientific Category :

  Natural Products

• Clinical Information :

  No Development Reported

• Isoform :

  MAO-A

• CAS Number :

  [90-47-1]