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IACS-15414

CAT: 0013-GTR19213372Size: 100 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19213372Size:100 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
IACS-15414 (IACS 15414) is a potent, selective, orally bioavailable SHP2 inhibitor with IC50 of 122 nM; IACS-15414 potently suppressed the mitogen-activated protein kinase (MAPK) pathway signaling and tumor growth in RTK-activated and KRASmut xenograft models in vivo. IACS-15414 potently suppressed the mitogen-activated protein kinase (MAPK) pathway signaling and tumor growth. IACS-15414 had excellent PK properties across species but a narrow hERG window.
CAS Number
2411321-29-2
Purity
>98%
Smiles
C1 (C) =NC (N2CCC3 (CO[C@@H] (C) [C@H]3N) CC2) =CC (=O) N1C1=CC=CC (Cl) =C1Cl
Molecular Formula
C20H24CL2N4O2
Molecular Weight
423.336162567139
Notes
For research use only.

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