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CDK8-IN-12

CAT: 0013-GTR19213052-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19213052-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
CDK8-IN-12 is a potent, selective, and orally bioavailable CDK8 inhibitor (Ki: 14 nM) with additional activity against GSK-3α/β and PCK-θ. It demonstrates anti-proliferative effects in MV4-11 leukemia cells and is a valuable chemical probe for researching transcription-dependent cancers and inflammatory diseases in experimental models.
CAS Number
2613307-67-6
Product Name Alternative
CDK8, CDK8IN12, CDK8-IN-12, GSK3, GSK-3α, GSK-3β
Field of Research
Cell Biology, Epigenetics & Chromatin, Signal Transduction, Stem Cell & Developmental Biology
Purity
98.55% (May vary between batches)
Solubility
DMSO:27.5 mg/mL (72.02 mM) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (5.24 mM)
Smiles
O=C1C2 (CCN (CC2) C=3C (=CN=CC3Cl) C4=CC=5C (O4) =CC=CC5) CCN1
Molecular Formula
C21H20ClN3O2
Molecular Weight
381.86
Storage Conditions
-20°C
Notes
For research use only.

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