Ixazomib

CAT: 0804-HY-10453-01Size: 5 mgDry Ice: NoHazardous: No

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CAT#:0804-HY-10453-01Size:5 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Description

Ixazomib (MLN2238) is a selective, potent, and reversible proteasome inhibitor, which inhibits the chymotrypsin-like proteolytic (β5) site of the 20S proteasome with an IC50 of 3.4 nM (Ki of 0.93 nM) .

CAS Number

1072833-77-2

Product Name Alternative

MLN2238

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Autophagy; Proteasome

Type

Reference compound

Related Pathways

Autophagy; Metabolic Enzyme/Protease

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/MLN2238.html

Purity

99.85

Solubility

DMSO : 62.5 mg/mL (ultrasonic)

Smiles

OB([C@@H](NC(CNC(C1=CC(Cl)=CC=C1Cl)=O)=O)CC(C)C)O

Molecular Formula

C14H19BCl2N2O4

Molecular Weight

361.03

Precautions

H302, H315, H319, H335

References & Citations

[1]Friedman JR, et al. Anticancer Activity of Natural and Synthetic Capsaicin Analogs. J Pharmacol Exp Ther. 2018 Mar;364 (3) :462-473.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

Launched

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Ixazomib

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