Ixazomib

• Target:

  Proteasome|||Caspase|||Autophagy

• Related Pathways:

  Proteases/Proteasome|||Apoptosis|||Autophagy|||Ubiquitination

• Purity:

  0.9977

• Bioactivity:

  Ixazomib (MLN2238), a second generation, boron-containing peptide proteasome inhibitor (PI), inhibits the chymotrypsin-like proteolytic (?5) site of the 20S proteasome (IC50/Ki: 3.4/0.93 nM, in cell-free assays), also inhibits the caspase-like (?1) and trypsin-like (?2) proteolytic sites (IC50: 31/3500 nM) .

• Smiles:

  CC(C)C[C@H](NC(=O)CNC(=O)c1cc(Cl)ccc1Cl)B(O)O

• Molecular Formula:

  C14H19BCl2N2O4

• Molecular Weight:

  361.03

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  1072833-77-2