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USP7-797

CAT: 0013-GTR19212289-02Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19212289-02Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
USP7-797 is a potent, selective, and orally active non-covalent USP7 inhibitor with an IC50 of 0.44 nM. It disrupts the USP7-ubiquitin interaction, demonstrating anti-tumor efficacy in vitro and in vivo by inducing apoptosis and suppressing growth in both wild-type and mutant p53 cancer cell lines.
CAS Number
2413944-70-2
Product Name Alternative
USP7-IN-7, USP7797, USP 7-797
Field of Research
Cell Biology, Epigenetics & Chromatin, Molecular Biology, Protein Biochemistry
Purity
95.90% (May vary between batches)
Solubility
DMSO:60 mg/mL (117.64 mM) ;10% DMSO+40% PEG300+5% Tween-80+45% Saline:3.3 mg/mL (6.47 mM)
Smiles
CC1 (C) C2C1C (=O) N (CC=3SC=4C (C3) =NC=CC4C5=C (C[C@@H]6CNCCO6) C (C) =CC (Cl) =C5) C2=O
Molecular Formula
C27H28ClN3O3S
Molecular Weight
510.05
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

Usp7-IN-7
CAS Number2413944-70-2
PubChem CID146445055
IUPAC Name3-[[7-[5-chloro-3-methyl-2-[[(2R)-morpholin-2-yl]methyl]phenyl]thieno[3,2-b]pyridin-2-yl]methyl]-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2,4-dione
Molecular FormulaC27H28ClN3O3S
Molecular Weight510.0
XLogP3.9
Topological Polar Surface Area99.8
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count6
Rotatable Bond Count5
Heavy Atom Count35
Formal Charge0
Complexity834
SMILES
CC1=CC(=CC(=C1C[C@@H]2CNCCO2)C3=C4C(=NC=C3)C=C(S4)CN5C(=O)C6C(C5=O)C6(C)C)Cl
InChI
InChI=1S/C27H28ClN3O3S/c1-14-8-15(28)9-20(19(14)10-16-12-29-6-7-34-16)18-4-5-30-21-11-17(35-24(18)21)13-31-25(32)22-23(26(31)33)27(22,2)3/h4-5,8-9,11,16,22-23,29H,6-7,10,12-13H2,1-3H3/t16-,22?,23?/m1/s1
InChIKey
DUAGQCVAGBJSHT-ZUTUBDCJSA-N
Chemical Structure
2D Structure
2D structure of Usp7-IN-7
CAS: 2413944-70-2
CID: 146445055
Formula: C27H28ClN3O3S
MW: 510.0
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight510.0
XLogP33.9
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count6
Rotatable Bond Count5
Exact Mass509.1539906
Monoisotopic Mass509.1539906
Topological Polar Surface Area99.8 Ų
Heavy Atom Count35
Formal Charge0
Complexity834
Isotope Atom Count0
Defined Atom Stereocenter Count1
Undefined Atom Stereocenter Count2
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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Alternative Products

CatalogName
T73234-01USP7-797
B2462-5ARRY-797
T68590-01FLA-797
339207-01USP7
T27787-01L-797,591
C8380-25NIR-797-isothiocyanate
HY-122227SMP-797 (hydrochloride)
TRC-I749005-100MGIR-797 chloride
MBS5778491SMP-797 HCl
sc-212395NIR-797 isothiocyanate

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