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GLPG3970

CAT: 0013-GTR19212154-05Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19212154-05Size:25 mg
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Description
GLPG3970 is an orally bioavailable, selective dual inhibitor of salt-inducible kinases 2 and 3 (SIK2/SIK3) . It demonstrates anti-inflammatory effects in preclinical models, supporting its research in autoimmune diseases such as psoriasis and rheumatoid arthritis through both in vitro and in vivo studies.
CAS Number
2403733-82-2
Product Name Alternative
SIK2, SIK3
Field of Research
Signal Transduction
Purity
99.60% (May vary between batches)
Solubility
DMSO:128.8 mg/mL (255.3 mM) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (6.54 mM)
Smiles
O=C1C=2C (OC) =CC (=CC2CCN1CC (F) (F) F) C3=CN=C4C=C (OCCN5CCOCC5) C=CN43
Molecular Formula
C25H27F3N4O4
Molecular Weight
504.5
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

UA6B2TI4MO
CAS Number2403733-82-2
PubChem CID146273261
IUPAC Name8-methoxy-6-[7-(2-morpholin-4-ylethoxy)imidazo[1,2-a]pyridin-3-yl]-2-(2,2,2-trifluoroethyl)-3,4-dihydroisoquinolin-1-one
Molecular FormulaC25H27F3N4O4
Molecular Weight504.5
XLogP3.6
Topological Polar Surface Area68.5
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count9
Rotatable Bond Count7
Heavy Atom Count36
Formal Charge0
Complexity753
SMILES
COC1=CC(=CC2=C1C(=O)N(CC2)CC(F)(F)F)C3=CN=C4N3C=CC(=C4)OCCN5CCOCC5
InChI
InChI=1S/C25H27F3N4O4/c1-34-21-13-18(12-17-2-4-31(16-25(26,27)28)24(33)23(17)21)20-15-29-22-14-19(3-5-32(20)22)36-11-8-30-6-9-35-10-7-30/h3,5,12-15H,2,4,6-11,16H2,1H3
InChIKey
XASOHFCUIQARJT-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of UA6B2TI4MO
CAS: 2403733-82-2
CID: 146273261
Formula: C25H27F3N4O4
MW: 504.5
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight504.5
XLogP33.6
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count9
Rotatable Bond Count7
Exact Mass504.19843984
Monoisotopic Mass504.19843984
Topological Polar Surface Area68.5 Ų
Heavy Atom Count36
Formal Charge0
Complexity753
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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