Etazolate

CAT: 0013-GTR19210752-01Size: 25 mgDry Ice: NoHazardous: No

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CAT#:0013-GTR19210752-01Size:25 mg

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Description

Etazolate is a phosphodiesterase 4 (PDE4) inhibitor exhibiting approximately 8-fold selectivity for cAMP over cGMP hydrolysis. This small molecule is utilized in research to study cAMP signaling pathways in neurological and inflammatory disease models, both in cellular and animal studies.

CAS Number

51022-77-6

Smiles

N (N=C (C) C) C1=C2C (N (CC) N=C2) =NC=C1C (OCC) =O

Molecular Formula

C14H19N5O2

Molecular Weight

289.33

Storage Conditions

-20°C

Notes

For research use only.

Chemical Information

Etazolate

Etazolate is a pyrazolopyridine that is 1H-pyrazolo[3,4-b]pyridine which is substituted at positions 1, 4, and 5 by ethyl, 2-isopropylidenehydrazino, and ethoxycarbonyl groups, respectively. A phosphodiesterase IV inhibitor with antidepressant and anxiolytic properties. It has a role as an antidepressant, an anxiolytic drug, an antipsychotic agent, a GABA agent, a neuroprotective agent, a phosphodiesterase IV inhibitor and an alpha-secretase activator. It is an ethyl ester, a hydrazone and a pyrazolopyridine.

CAS Number	51022-77-6
PubChem CID	3277
IUPAC Name	ethyl 1-ethyl-4-(2-propan-2-ylidenehydrazinyl)pyrazolo[3,4-b]pyridine-5-carboxylate
Molecular Formula	C14H19N5O2
Molecular Weight	289.33
XLogP	2.1
Topological Polar Surface Area	81.4
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	6
Rotatable Bond Count	6
Heavy Atom Count	21
Formal Charge	0
Complexity	397

SMILES

CCN1C2=NC=C(C(=C2C=N1)NN=C(C)C)C(=O)OCC

InChI

InChI=1S/C14H19N5O2/c1-5-19-13-10(8-16-19)12(18-17-9(3)4)11(7-15-13)14(20)21-6-2/h7-8H,5-6H2,1-4H3,(H,15,18)

InChIKey

OPQRBXUBWHDHPQ-UHFFFAOYSA-N

Chemical Structure

2D Structure

CAS: 51022-77-6

CID: 3277

Formula: C14H19N5O2

MW: 289.33

Interactive 3D Structure

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View on PubChem Raw 3D data

Computed Properties

Property	Value
Molecular Weight	289.33
XLogP3	2.1
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	6
Rotatable Bond Count	6
Exact Mass	289.15387487
Monoisotopic Mass	289.15387487
Topological Polar Surface Area	81.4 Å²
Heavy Atom Count	21
Formal Charge	0
Complexity	397
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Compound Is Canonicalized	Yes

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Alternative Products

Catalog	Name
574687	Etazolate
TRC-E889255-250MG	Etazolate Hydrochloride
HY-100936-01	Etazolate (hydrochloride)
MBS6061389-01	Etazolate (SQ 20009)
HY-100936R-01	Etazolate (hydrochloride) (Standard)

Etazolate

Chemical Information

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