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AG-012986 HCl

CAT: 0013-GTR19210723-01Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19210723-01Size:25 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
AG-012986 HCl is a potent and selective multi-CDK inhibitor targeting CDK1, 2, 4/6, 5, and 9. It demonstrates robust in vitro antiproliferative activity and induces significant tumor growth inhibition in vivo across multiple human xenograft models, correlating with Rb hypophosphorylation, cell cycle arrest, and apoptosis. This profile supports its use in oncology research, particularly in studying cell cycle dynamics and CDK-targeted therapies.
CAS Number
486414-32-8
Smiles
C (=O) (C=1SC (NC2=CC=C (C (N[C@@H] (CN (C) C) C) =O) C=C2) =NC1N) C3=C (F) C=CC=C3F.Cl.Cl
Molecular Formula
C22H25Cl2F2N5O2S
Molecular Weight
532.43
Storage Conditions
-20°C
Notes
For research use only.

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