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AG-012986

CAT: 0013-GTR19210725-01Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19210725-01Size:25 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
AG-012986 is a potent and selective multi-CDK inhibitor targeting CDK1, 2, 4/6, 5, and 9. It demonstrates robust in vitro antiproliferative activity and induces significant tumor growth inhibition in vivo across multiple human xenograft models, associated with Rb hypophosphorylation, cell cycle arrest, and apoptosis. This profile supports its research use in oncology, particularly for studying cell cycle dysregulation and evaluating CDK inhibition as a therapeutic strategy.
CAS Number
486414-35-1
Field of Research
Cell Biology
Smiles
C (=O) (C=1SC (NC2=CC=C (C (N[C@@H] (CN (C) C) C) =O) C=C2) =NC1N) C3=C (F) C=CC=C3F
Molecular Formula
C22H23F2N5O2S
Molecular Weight
459.51
Storage Conditions
-20°C
Notes
For research use only.

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