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EP4 Antagonist 14

CAT: 0013-GTR19219873-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19219873-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
EP4 antagonist 14 is a potent and selective EP4 receptor blocker, exhibiting sub-nanomolar IC50 values in HEK293 reporter and β-arrestin recruitment assays. In vitro, it suppresses PGE2-induced expression of various M2-like macrophage markers in RAW 264.7 cells. In vivo, it synergizes with anti-PD-1 therapy to inhibit tumor growth and increase intratumoral CD8+ T cell infiltration in a CT26 colon carcinoma model.
Field of Research
Pharmacology & Drug Discovery
Smiles
O=C (O) C1=CC=C (CNC (C2=C3C=CC=CC3=NN2CC4=CC=C (C (F) (F) F) C=C4) =O) C=C1
Molecular Formula
C24H18F3N3O3
Molecular Weight
453.41
Storage Conditions
-20°C
Notes
For research use only.

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