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AZD-4877

CAT: 0013-GTR19213750-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19213750-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
AZD-4877 is a highly potent Eg5 kinesin inhibitor (IC50 = 2 nM) that disrupts mitotic spindle formation, leading to a characteristic monopolar spindle phenotype, cell cycle arrest, and apoptosis. It demonstrates antitumor activity in preclinical models and has been shown to inhibit the proliferation of peripheral blood mononuclear cells in vitro.
CAS Number
758722-49-5
Product Name Alternative
AZD 4877, AZD4877, AZD-4877, Apoptosis, Eg5
Field of Research
Cell Biology, Signal Transduction
Purity
99.19% (May vary between batches)
Solubility
DMSO:55 mg/mL (109.2 mM) ;10% DMSO+40% PEG300+5% Tween-80+45% Saline:5 mg/mL (9.93 mM)
Smiles
C (N (C (=O) C1=CC=C (C) C=C1) CCCN) (C (C) C) C=2N (CC3=CC=CC=C3) C (=O) C4=C (N2) SN=C4C
Molecular Formula
C28H33N5O2S
Molecular Weight
503.66
Storage Conditions
-20°C
Notes
For research use only.

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