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5'-Hydroxy-staurosporine

CAT: 0013-GTR19210538-01Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19210538-01Size:25 mg
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Description
5'-Hydroxy-staurosporine is a cell-permeable AMPK inhibitor that exhibits selective cytotoxicity against human colon carcinoma cell lines. It is a valuable research tool for studying AMPK signaling in cancer metabolism and for in vitro investigations of tumor cell viability and apoptosis.
CAS Number
308847-74-7
Field of Research
Infectious Disease & Virology
Smiles
C[C@]12N3C=4C5=C (C6=C (C4C=7C3=CC=CC7) CNC6=O) C=8C (N5[C@] (O1) ([C@H] (O) [C@@H] (NC) [C@H]2OC) [H]) =CC=CC8
Molecular Formula
C28H26N4O4
Molecular Weight
482.53
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

5'-Hydroxystaurosporine

5'-hydroxystaurosporine is an indolocarbazole.

CAS Number308847-74-7
PubChem CID139583747
IUPAC Name(2R,3S,4S,5S,6S)-5-hydroxy-3-methoxy-2-methyl-4-(methylamino)-29-oxa-1,7,17-triazaoctacyclo[12.12.2.12,6.07,28.08,13.015,19.020,27.021,26]nonacosa-8,10,12,14,19,21,23,25,27-nonaen-16-one
Molecular FormulaC28H26N4O4
Molecular Weight482.5
XLogP2.3
Topological Polar Surface Area89.7
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count5
Rotatable Bond Count2
Heavy Atom Count36
Formal Charge0
Complexity935
SMILES
C[C@]12[C@H]([C@H]([C@@H]([C@H](O1)N3C4=CC=CC=C4C5=C6C(=C7C8=CC=CC=C8N2C7=C53)CNC6=O)O)NC)OC
InChI
InChI=1S/C28H26N4O4/c1-28-25(35-3)21(29-2)24(33)27(36-28)31-16-10-6-4-8-13(16)19-20-15(12-30-26(20)34)18-14-9-5-7-11-17(14)32(28)23(18)22(19)31/h4-11,21,24-25,27,29,33H,12H2,1-3H3,(H,30,34)/t21-,24-,25-,27-,28+/m0/s1
InChIKey
QKBKQHZMMIJMJW-JSEZCHGOSA-N
Chemical Structure
2D Structure
2D structure of 5'-Hydroxystaurosporine
CAS: 308847-74-7
CID: 139583747
Formula: C28H26N4O4
MW: 482.5
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight482.5
XLogP32.3
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count5
Rotatable Bond Count2
Exact Mass482.19540532
Monoisotopic Mass482.19540532
Topological Polar Surface Area89.7 Ų
Heavy Atom Count36
Formal Charge0
Complexity935
Isotope Atom Count0
Defined Atom Stereocenter Count5
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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