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AFN941

CAT: 0013-GTR19210199-03Size: 100 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19210199-03Size:100 mg
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Description
AFN941 is a staurosporine-derived small molecule that selectively inhibits Janus kinase 3 (Jak3) . This inhibitor is utilized in biochemical and cellular research to study Jak3-dependent signaling pathways in immunology and oncology, supporting both in vitro and in vivo experimental models.
CAS Number
220038-19-7
Field of Research
Cardiovascular Research, Epigenetics & Chromatin, Signal Transduction, Stem Cell & Developmental Biology
Smiles
C[C@]12N3C=4C5=C (C6=C (C4C=7C3=CC=CC7) CNC6=O) C8=C (N5[C@] (O1) (C[C@@H] (NC) [C@H]2OC) [H]) CCCC8
Molecular Formula
C28H30N4O3
Molecular Weight
470.56
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

Afn941
CAS Number220038-19-7
PubChem CID4369398
IUPAC Name(2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-29-oxa-1,7,17-triazaoctacyclo[12.12.2.12,6.07,28.08,13.015,19.020,27.021,26]nonacosa-8(13),14,19,21,23,25,27-heptaen-16-one
Molecular FormulaC28H30N4O3
Molecular Weight470.6
XLogP3.1
Topological Polar Surface Area69.5
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count4
Rotatable Bond Count2
Heavy Atom Count35
Formal Charge0
Complexity901
SMILES
C[C@@]12[C@@H]([C@@H](C[C@@H](O1)N3C4=C(CCCC4)C5=C6C(=C7C8=CC=CC=C8N2C7=C53)CNC6=O)NC)OC
InChI
InChI=1S/C28H30N4O3/c1-28-26(34-3)17(29-2)12-20(35-28)31-18-10-6-4-8-14(18)22-23-16(13-30-27(23)33)21-15-9-5-7-11-19(15)32(28)25(21)24(22)31/h5,7,9,11,17,20,26,29H,4,6,8,10,12-13H2,1-3H3,(H,30,33)/t17-,20-,26-,28+/m1/s1
InChIKey
KIZWKTROWIIMNN-FYTWVXJKSA-N
Chemical Structure
2D Structure
2D structure of Afn941
CAS: 220038-19-7
CID: 4369398
Formula: C28H30N4O3
MW: 470.6
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight470.6
XLogP33.1
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count4
Rotatable Bond Count2
Exact Mass470.23179083
Monoisotopic Mass470.23179083
Topological Polar Surface Area69.5 Ų
Heavy Atom Count35
Formal Charge0
Complexity901
Isotope Atom Count0
Defined Atom Stereocenter Count4
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
T69812-01AFN941

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