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PS-519

CAT: 0013-GTR19210119-01Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19210119-01Size:25 mg
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Description
PS-519 is a dual-function small molecule research compound that acts as an inhibitor of both tissue plasminogen activator (tPA) and the proteasome. It is utilized in biochemical and pharmacological studies to investigate proteolytic pathways, with applications in cellular and in vivo models of thrombosis and proteasome-related diseases.
CAS Number
211866-70-5
Smiles
[C@@H] (C (C) C) (O) [C@]12[C@] ([C@@H] (CCC) C (=O) N1) (OC2=O) [H]
Molecular Formula
C12H19NO4
Molecular Weight
241.28
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

PS-519

PS-519 is a beta-lactone proteasome inhibitor derived from lactacystin. It has a role as a proteasome inhibitor. It is a lactam and a beta-lactone. It is functionally related to a lactacystin.

CAS Number211866-70-5
PubChem CID9877196
IUPAC Name(1R,4R,5S)-1-[(1S)-1-hydroxy-2-methylpropyl]-4-propyl-6-oxa-2-azabicyclo[3.2.0]heptane-3,7-dione
Molecular FormulaC12H19NO4
Molecular Weight241.28
XLogP1.6
Topological Polar Surface Area75.6
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count4
Rotatable Bond Count4
Heavy Atom Count17
Formal Charge0
Complexity354
SMILES
CCC[C@@H]1[C@H]2[C@](C(=O)O2)(NC1=O)[C@H](C(C)C)O
InChI
InChI=1S/C12H19NO4/c1-4-5-7-9-12(11(16)17-9,13-10(7)15)8(14)6(2)3/h6-9,14H,4-5H2,1-3H3,(H,13,15)/t7-,8+,9+,12-/m1/s1
InChIKey
KMXHEXRPYSXLRN-JDVQERKKSA-N
Chemical Structure
2D Structure
2D structure of PS-519
CAS: 211866-70-5
CID: 9877196
Formula: C12H19NO4
MW: 241.28
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight241.28
XLogP31.6
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count4
Rotatable Bond Count4
Exact Mass241.13140809
Monoisotopic Mass241.13140809
Topological Polar Surface Area75.6 Ų
Heavy Atom Count17
Formal Charge0
Complexity354
Isotope Atom Count0
Defined Atom Stereocenter Count4
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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T69890-01PS-519
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C8482-100JTV-519 fumarate
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