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APS-2-79

CAT: 0013-GTR19209998-01Size: 100 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19209998-01Size:100 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
APS-2-79 is a potent, KSR-dependent allosteric MEK inhibitor with an IC50 of 120 nM. It functions by blocking ATP binding within the KSR2-MEK1 complex, stabilizing KSR's inactive conformation to suppress oncogenic Ras-MAPK signaling. This compound is a valuable chemical probe for investigating Ras-driven cancers in both cellular and animal models.
CAS Number
2002381-25-9
Field of Research
Signal Transduction
Smiles
COc1cc2ncnc (Nc3ccc (Oc4ccccc4) cc3C) c2cc1OC
Molecular Formula
C23H21N3O3
Molecular Weight
387.43
Storage Conditions
-20°C
Notes
For research use only.

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