Products for Research Use Only
RegisterLogin

(S) -Enitociclib

CAT: 0013-GTR19209592-01Size: 1 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0013-GTR19209592-01Size:1 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
(S) -Enitociclib (VIP152) is a potent and selective CDK9 inhibitor that suppresses RNA polymerase II-driven transcription, leading to the downregulation of pro-survival proteins and complete regression of MYC-driven lymphomas in vivo. Its application extends to oncology research, particularly in studying transcription-dependent cancers, with efficacy demonstrated in both cellular and animal models.
CAS Number
1610408-97-3
Product Name Alternative
CDK9, BMS986126, BMS 986126, VIP 152, VIP152, VIP-152
Field of Research
Cell Biology, Molecular Biology
Purity
98.04% (May vary between batches)
Smiles
COC1=C (C2=C (F) C=NC (NC3=CC (C[S@@] (C) (=N) =O) =CC=N3) =C2) C=CC (F) =C1
Molecular Formula
C19H18F2N4O2S
Molecular Weight
404.43
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

Enitociclib

Enitociclib is an inhibitor of cyclin-dependent kinase 9 (CDK9), the catalytic subunit of the RNA polymerase II (RNA Pol II) elongation factor positive transcription elongation factor b (PTEF- b; PTEFb), with potential antineoplastic activity. Upon administration, enitociclib binds to and blocks the phosphorylation and kinase activity of CDK9, thereby preventing PTEFb-mediated activation of RNA Pol II and leading to the inhibition of gene transcription of various anti-apoptotic proteins. This may cause cell cycle arrest and induce apoptosis, which may lead to a reduction in tumor cell proliferation. The protein complex PTEF-b, a heterodimer consisting of CDK9 and a regulatory cyclin subunit of the T family, is over-activated in various tumor cell types; it plays a key role in the regulation of Pol II-mediated transcription of anti-apoptotic proteins. Tumor cells are dependent on anti-apoptotic proteins for their survival.

CAS Number1610408-97-3
PubChem CID139593425
IUPAC Name5-fluoro-4-(4-fluoro-2-methoxyphenyl)-N-[4-[(methylsulfonimidoyl)methyl]-2-pyridinyl]pyridin-2-amine
Molecular FormulaC19H18F2N4O2S
Molecular Weight404.4
XLogP4.2
Topological Polar Surface Area96.3
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count8
Rotatable Bond Count6
Heavy Atom Count28
Formal Charge0
Complexity619
SMILES
COC1=C(C=CC(=C1)F)C2=CC(=NC=C2F)NC3=NC=CC(=C3)C[S@@](=N)(=O)C
InChI
InChI=1S/C19H18F2N4O2S/c1-27-17-8-13(20)3-4-14(17)15-9-19(24-10-16(15)21)25-18-7-12(5-6-23-18)11-28(2,22)26/h3-10,22H,11H2,1-2H3,(H,23,24,25)/t28-/m0/s1
InChIKey
YZCUMZWULWOUMD-NDEPHWFRSA-N
Chemical Structure
2D Structure
2D structure of Enitociclib
CAS: 1610408-97-3
CID: 139593425
Formula: C19H18F2N4O2S
MW: 404.4
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight404.4
XLogP34.2
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count8
Rotatable Bond Count6
Exact Mass404.11185333
Monoisotopic Mass404.11185333
Topological Polar Surface Area96.3 Ų
Heavy Atom Count28
Formal Charge0
Complexity619
Isotope Atom Count0
Defined Atom Stereocenter Count1
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Related Products

CatalogName
GTR19260786-01(+) -Enitociclib
GTR19175586-01(±) -Enitociclib
GTR19219915-01(R) -Enitociclib
GTR19264533-01(S, S, S) -AHPC
GTR19275104-01(S, S, S) -VH032
GTR19156201-01(S, S, S) -AHPC hydrochloride
GTR19175768-01(S, S, S) -AHPC hydrochloride
GTR19264703-01(S, S, S) -AHPC-Me
GTR19257852-01(R, S, S, S) -Orlistat
GTR19196063-01(S, S) -D211

Alternative Products

CatalogName
HY-103019A-01(±) -Enitociclib
T13420-01(-)-Enitociclib
HY-103019B-01(-) -Enitociclib
HY-103019-01Enitociclib
T13420L-01(+)-Enitociclib
BUP01031-01(R) -Enitociclib
T70388-01(S) -Enitociclib
C13624-10mM/1mLEnitociclib (BAY 1251152)

Popular Products