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GNE-431

CAT: 0013-GTR19209402-01Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19209402-01Size:25 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
GNE-431 is a highly potent and selective noncovalent inhibitor of Bruton's tyrosine kinase (Btk), demonstrating an IC50 of 3.2 nM. It effectively targets Btk mutants, including C481R and T474I/M, offering a promising research tool for studying resistance mechanisms to covalent inhibitors like ibrutinib in both cellular and in vivo models of B-cell malignancies.
CAS Number
1433820-83-7
Field of Research
Cardiovascular Research, Signal Transduction
Smiles
O=C1C=2N (C3=C (C2) CCCC3) CCN1C4=C (CO) C (=CC=N4) C=5C=C (NC=6C=C7N (N6) CCN (C) C7) C=8N (N5) C=CN8
Molecular Formula
C30H32N10O2
Molecular Weight
564.64
Storage Conditions
-20°C
Notes
For research use only.

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