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KRIBB3

CAT: 0013-GTR19208922Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19208922Size:5 mg
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Description
KRIBB3 is a novel, potent microtubule inhibitor with demonstrated anticancer activity. It exhibits anti-migratory and anti-invasive effects in MDA-MB-231 cells by directly binding to Hsp27 and inhibiting its PKC-dependent phosphorylation. This mechanism supports its investigation in metastasis research and in vitro cell migration assays.
CAS Number
129414-88-6
Field of Research
Cell Biology, Signal Transduction
Smiles
OC=1C (C2=C (C=NO2) C3=CC=C (OC) C=C3) =CC (CC) =C (OC) C1
Molecular Formula
C19H19NO4
Molecular Weight
325.36
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

5-(5-Ethyl-2-hydroxy-4-methoxyphenyl)-4-(4-methoxyphenyl)isoxazole

inhibits Hsp27 phosphorylation; structure in first source

CAS Number129414-88-6
PubChem CID927908
IUPAC Name4-ethyl-5-methoxy-2-[4-(4-methoxyphenyl)-1,2-oxazol-5-yl]phenol
Molecular FormulaC19H19NO4
Molecular Weight325.4
XLogP4
Topological Polar Surface Area64.7
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count5
Rotatable Bond Count5
Heavy Atom Count24
Formal Charge0
Complexity386
SMILES
CCC1=CC(=C(C=C1OC)O)C2=C(C=NO2)C3=CC=C(C=C3)OC
InChI
InChI=1S/C19H19NO4/c1-4-12-9-15(17(21)10-18(12)23-3)19-16(11-20-24-19)13-5-7-14(22-2)8-6-13/h5-11,21H,4H2,1-3H3
InChIKey
BNBHIGLOMVMJDB-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of 5-(5-Ethyl-2-hydroxy-4-methoxyphenyl)-4-(4-methoxyphenyl)isoxazole
CAS: 129414-88-6
CID: 927908
Formula: C19H19NO4
MW: 325.4
Interactive 3D Structure
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View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight325.4
XLogP34
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count5
Rotatable Bond Count5
Exact Mass325.13140809
Monoisotopic Mass325.13140809
Topological Polar Surface Area64.7 Ų
Heavy Atom Count24
Formal Charge0
Complexity386
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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