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Gilteritinib hemifumarate

CAT: 0013-GTR19208914-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19208914-01Size:1 mg
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Description
Gilteritinib hemifumarate (ASP2215 hemifumarate) is a highly potent, ATP-competitive dual inhibitor targeting FLT3 and AXL kinases, with IC50 values of 0.29 nM and 0.73 nM, respectively. It is a key research compound for studying relapsed or refractory FLT3-mutant acute myeloid leukemia (AML), utilized in both in vitro cellular assays and in vivo xenograft models to investigate therapeutic mechanisms and resistance.
CAS Number
1254053-84-3
Product Name Alternative
Gilteritinib, Gilteritinib Hemifumarate, FLT3, AXL, ASP 2215, ASP 2215 Hemifumarate, ASP2215, ASP-2215, ASP2215 Hemifumarate, ASP2215 hemifumarate, ASP-2215 Hemifumarate, TAM Receptor, TAMReceptor
Field of Research
Cardiovascular Research, Pharmacology & Drug Discovery, Signal Transduction
Purity
98.07% (May vary between batches)
Solubility
H2O:1 mg/mL (1.64 mM) ; DMSO:3 mg/mL (4.91 mM)
Smiles
C (=C/C (O) =O) \C (O) =O.N (C=1C (C (N) =O) =NC (CC) =C (NC2CCOCC2) N1) C3=CC (OC) =C (C=C3) N4CCC (CC4) N5CCN (C) CC5
Molecular Formula
C29H44N8O3.1/2C4H4O4
Molecular Weight
610.75
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

Gilteritinib Fumarate

Gilteritinib Fumarate is the fumarate salt form of gilteritinib, an orally bioavailable inhibitor of the receptor tyrosine kinases (RTKs) FMS-like tyrosine kinase 3 (FLT3; STK1; FLK2), AXL (UFO; JTK11), anaplastic lymphoma kinase (ALK; CD246), and leukocyte receptor tyrosine kinase (LTK), with potential antineoplastic activity. Upon administration, gilteritinib binds to and inhibits both the wild-type and mutated forms of FLT3, AXL, ALK and LTK. This may result in an inhibition of FLT3-, AXL-, ALK-, and LTK-mediated signal transduction pathways and reduced proliferation in cancer cells that overexpress these RTKs. FLT3, AXL, ALK, and LTK, which are overexpressed or mutated in a variety of cancer cell types, play key roles in tumor cell growth and survival.

CAS Number1254053-84-3
PubChem CID76970819
IUPAC Name(E)-but-2-enedioic acid;bis(6-ethyl-3-[3-methoxy-4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]anilino]-5-(oxan-4-ylamino)pyrazine-2-carboxamide)
Molecular FormulaC62H92N16O10
Molecular Weight1221.5
Topological Polar Surface Area317
Hydrogen Bond Donor Count8
Hydrogen Bond Acceptor Count24
Rotatable Bond Count20
Heavy Atom Count88
Formal Charge0
Complexity904
SMILES
CCC1=C(N=C(C(=N1)C(=O)N)NC2=CC(=C(C=C2)N3CCC(CC3)N4CCN(CC4)C)OC)NC5CCOCC5.CCC1=C(N=C(C(=N1)C(=O)N)NC2=CC(=C(C=C2)N3CCC(CC3)N4CCN(CC4)C)OC)NC5CCOCC5.C(=C/C(=O)O)\C(=O)O
InChI
InChI=1S/2C29H44N8O3.C4H4O4/c2*1-4-23-28(31-20-9-17-40-18-10-20)34-29(26(33-23)27(30)38)32-21-5-6-24(25(19-21)39-3)37-11-7-22(8-12-37)36-15-13-35(2)14-16-36;5-3(6)1-2-4(7)8/h2*5-6,19-20,22H,4,7-18H2,1-3H3,(H2,30,38)(H2,31,32,34);1-2H,(H,5,6)(H,7,8)/b;;2-1+
InChIKey
UJOUWHLYTQFUCU-WXXKFALUSA-N
Chemical Structure
2D Structure
2D structure of Gilteritinib Fumarate
CAS: 1254053-84-3
CID: 76970819
Formula: C62H92N16O10
MW: 1221.5
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight1221.5
Hydrogen Bond Donor Count8
Hydrogen Bond Acceptor Count24
Rotatable Bond Count20
Exact Mass1220.71823320
Monoisotopic Mass1220.71823320
Topological Polar Surface Area317 Ų
Heavy Atom Count88
Formal Charge0
Complexity904
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count1
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count3
Compound Is CanonicalizedYes

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