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Navamepent

CAT: 0013-GTR19208525-02Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19208525-02Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Navamepent (RX-10045) is a resolvin E1 analog with potent anti-inflammatory properties, effectively reducing corneal inflammation and promoting tissue repair in dry eye models. It inhibits pro-inflammatory mediator release in corneal epithelial cells and has demonstrated efficacy in accelerating tear production and reducing goblet cell loss in preclinical studies.
CAS Number
1251537-11-7
Product Name Alternative
RX 10045, RX10045, RX-10045, Navamepent
Purity
98.84% (May vary between batches)
Solubility
DMSO:50 mg/mL (164.27 mM) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (6.57 mM)
Smiles
C (C[C@@H] (C#C/C=C/C=C/[C@@H] (CC#C) O) O) CC (OC (C) C) =O
Molecular Formula
C18H24O4
Molecular Weight
304.38
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

Navamepent

Navamepent is a small molecule drug. Navamepent is under investigation in clinical trial NCT02329743 (Efficacy and Safety of RX-10045 Ophthalmic Solution for Ocular Inflammation and Pain in Cataract Surgery). Navamepent has a monoisotopic molecular weight of 304.17 Da.

CAS Number1251537-11-7
PubChem CID46926878
IUPAC Namepropan-2-yl (5S,8E,10E,12R)-5,12-dihydroxypentadeca-8,10-dien-6,14-diynoate
Molecular FormulaC18H24O4
Molecular Weight304.4
XLogP2.2
Topological Polar Surface Area66.8
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count4
Rotatable Bond Count9
Heavy Atom Count22
Formal Charge0
Complexity493
SMILES
CC(C)OC(=O)CCC[C@@H](C#C/C=C/C=C/[C@@H](CC#C)O)O
InChI
InChI=1S/C18H24O4/c1-4-10-16(19)11-7-5-6-8-12-17(20)13-9-14-18(21)22-15(2)3/h1,5-7,11,15-17,19-20H,9-10,13-14H2,2-3H3/b6-5+,11-7+/t16-,17-/m1/s1
InChIKey
ZVOCIIHCJJEFRQ-BHXBHYJPSA-N
Chemical Structure
2D Structure
2D structure of Navamepent
CAS: 1251537-11-7
CID: 46926878
Formula: C18H24O4
MW: 304.4
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight304.4
XLogP32.2
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count4
Rotatable Bond Count9
Exact Mass304.16745924
Monoisotopic Mass304.16745924
Topological Polar Surface Area66.8 Ų
Heavy Atom Count22
Formal Charge0
Complexity493
Isotope Atom Count0
Defined Atom Stereocenter Count2
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count2
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
T71704-01Navamepent

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