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OSU-53

CAT: 0013-GTR19208334-02Size: 50 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19208334-02Size:50 mg
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Description
OSU-53 is a small molecule activator of AMPK, which consequently inhibits mTOR signaling and stimulates autophagy. It has also been shown to activate pathways in cells with mutations in RAS or BRAF. This compound is used in cancer research, particularly for studying metabolic signaling and oncogenic pathways in both cellular and animal models.
CAS Number
1290069-19-0
Field of Research
Cell Biology, Epigenetics & Chromatin, Signal Transduction
Smiles
S (NC1=CC=C (/C=C\2/C (=O) N (CC3 (C) CCCCC3) C (=O) S2) C=C1) (=O) (=O) C4=CC (C (F) (F) F) =C (N (=O) =O) C=C4
Molecular Formula
C25H24F3N3O6S2
Molecular Weight
583.6
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

Osu-53

an AMPK activator and mTOR inhibitor; structure in first source

CAS Number1290069-19-0
PubChem CID45378798
IUPAC NameN-[4-[(Z)-[3-[(1-methylcyclohexyl)methyl]-2,4-dioxo-1,3-thiazolidin-5-ylidene]methyl]phenyl]-4-nitro-3-(trifluoromethyl)benzenesulfonamide
Molecular FormulaC25H24F3N3O6S2
Molecular Weight583.6
XLogP6.4
Topological Polar Surface Area163
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count11
Rotatable Bond Count6
Heavy Atom Count39
Formal Charge0
Complexity1090
SMILES
CC1(CCCCC1)CN2C(=O)/C(=C/C3=CC=C(C=C3)NS(=O)(=O)C4=CC(=C(C=C4)[N+](=O)[O-])C(F)(F)F)/SC2=O
InChI
InChI=1S/C25H24F3N3O6S2/c1-24(11-3-2-4-12-24)15-30-22(32)21(38-23(30)33)13-16-5-7-17(8-6-16)29-39(36,37)18-9-10-20(31(34)35)19(14-18)25(26,27)28/h5-10,13-14,29H,2-4,11-12,15H2,1H3/b21-13-
InChIKey
FANMQRSNMHKZCR-BKUYFWCQSA-N
Chemical Structure
2D Structure
2D structure of Osu-53
CAS: 1290069-19-0
CID: 45378798
Formula: C25H24F3N3O6S2
MW: 583.6
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight583.6
XLogP36.4
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count11
Rotatable Bond Count6
Exact Mass583.10586233
Monoisotopic Mass583.10586233
Topological Polar Surface Area163 Ų
Heavy Atom Count39
Formal Charge0
Complexity1090
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count1
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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HY-125535OSU-53
5-05754Boc-Glu(OSu)-OSu
5-06519Fmoc-Glu(OSu)-OSu
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