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OSU-T315

CAT: 0013-GTR19163831-01Size: 200 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19163831-01Size:200 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
A novel potent, orally active ILK (integrin-linked kinase) inhibitor with IC50 of 0.6 uM; exhibits high in vitro potency against a panel of prostate and breast cancer cell lines (IC50=1-2.5 uM) with no effect on normal epithelial cells; facilitates the dephosphorylation of Akt at Ser-473 and other ILK targets, including GSK-3β and myosin light chain; suppresses the expression of the transcription/translation factor YB-1 and HER2, EGFR in PC-3 cells, induces autophagy and apoptosis; demonstrates in vivo efficacy in suppressing PC-3 xenograft tumor growth; orally active.
CAS Number
1333146-24-9
Product Name Alternative
OSU-T 315
Purity
>98% (HPLC)
Solubility
10 mM in DMSO
Smiles
O=C (NC) CCC1=NN (C2=CC=C (N3CCNCC3) C=C2) C (C4=CC=C (C5=CC=C (C (F) (F) F) C=C5) C=C4) =C1
Molecular Formula
C30H30F3N5O
Molecular Weight
533.5873
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
1H-Pyrazole-3-propanamide, N-methyl-1-[4- (1-piperazinyl) phenyl]-5-[4'- (trifluoromethyl) [1,1'-biphenyl]-4-yl]-

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Alternative Products

CatalogName
C12259-5mgOSU-T315
A20870-50OSU-T315 50mg
A20870-10OSU-T315 10mg
A20870-1OSU-T315 1mg
A20870-500OSU-T315 500mg
A20870-5OSU-T315 5mg
A20870-100OSU-T315 100mg
A20870-25OSU-T315 25mg
A20870-2OSU-T315 2mg
M20219-01OSU-T315 (15-regioisomer)

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