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SAR156497

CAT: 0013-GTR19208272-01Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19208272-01Size:25 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
SAR156497 is a highly potent and selective pan-Aurora kinase inhibitor (IC50: 0.5-3 nM) demonstrating robust in vitro antiproliferative activity and in vivo target modulation. It effectively induces polyploidy and modulates biomarkers like pHH3, making it a valuable chemical probe for cancer research, particularly in studying mitosis and kinase signaling pathways.
CAS Number
1256137-14-0
Field of Research
Cell Biology, Epigenetics & Chromatin, Metabolism Research
Smiles
O=C1C=2[C@H] (C=3C (=C (C (OCC) =O) NC3) NC2CCC1) C4=CC (OC=5NC=6C (N5) =CC=CC6) =CC=C4
Molecular Formula
C27H24N4O4
Molecular Weight
468.5
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

ethyl 9-[3-(1H-benzimidazol-2-yloxy)phenyl]-8-oxo-2,4,5,6,7,9-hexahydropyrrolo[3,4-b]quinoline-3-carboxylate
CAS Number1256137-14-0
PubChem CID49800670
IUPAC Nameethyl 9-[3-(1H-benzimidazol-2-yloxy)phenyl]-8-oxo-2,4,5,6,7,9-hexahydropyrrolo[3,4-b]quinoline-3-carboxylate
Molecular FormulaC27H24N4O4
Molecular Weight468.5
XLogP4.4
Topological Polar Surface Area109
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count6
Rotatable Bond Count6
Heavy Atom Count35
Formal Charge0
Complexity862
SMILES
CCOC(=O)C1=C2C(=CN1)C(C3=C(N2)CCCC3=O)C4=CC(=CC=C4)OC5=NC6=CC=CC=C6N5
InChI
InChI=1S/C27H24N4O4/c1-2-34-26(33)25-24-17(14-28-25)22(23-20(29-24)11-6-12-21(23)32)15-7-5-8-16(13-15)35-27-30-18-9-3-4-10-19(18)31-27/h3-5,7-10,13-14,22,28-29H,2,6,11-12H2,1H3,(H,30,31)
InChIKey
YXMQIWJYPNBZJS-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of ethyl 9-[3-(1H-benzimidazol-2-yloxy)phenyl]-8-oxo-2,4,5,6,7,9-hexahydropyrrolo[3,4-b]quinoline-3-carboxylate
CAS: 1256137-14-0
CID: 49800670
Formula: C27H24N4O4
MW: 468.5
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight468.5
XLogP34.4
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count6
Rotatable Bond Count6
Exact Mass468.17975526
Monoisotopic Mass468.17975526
Topological Polar Surface Area109 Ų
Heavy Atom Count35
Formal Charge0
Complexity862
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count1
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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