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C-Fms-IN-8

CAT: 0013-GTR19206352-01Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19206352-01Size:25 mg
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Description
C-Fms-IN-8 is a potent and selective Type II inhibitor of the CSF-1R (c-FMS) kinase with an IC50 of 9.1 nM. This compound is utilized in preclinical research to investigate the role of CSF-1R signaling in oncology and immunology, supporting both in vitro cellular assays and in vivo model studies.
CAS Number
1255303-58-2
Field of Research
Signal Transduction
Smiles
CCc1ccc (COc2ccc (cc2OC) C2CN (C2) C (=O) c2cc (OCCO) ccn2) cc1
Molecular Formula
C27H30N2O5
Molecular Weight
462.54
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

c-Fms-IN-8
CAS Number1255303-58-2
PubChem CID59634061
IUPAC Name[3-[4-[(4-ethylphenyl)methoxy]-3-methoxyphenyl]azetidin-1-yl]-[4-(2-hydroxyethoxy)-2-pyridinyl]methanone
Molecular FormulaC27H30N2O5
Molecular Weight462.5
XLogP3.7
Topological Polar Surface Area81.1
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count6
Rotatable Bond Count10
Heavy Atom Count34
Formal Charge0
Complexity620
SMILES
CCC1=CC=C(C=C1)COC2=C(C=C(C=C2)C3CN(C3)C(=O)C4=NC=CC(=C4)OCCO)OC
InChI
InChI=1S/C27H30N2O5/c1-3-19-4-6-20(7-5-19)18-34-25-9-8-21(14-26(25)32-2)22-16-29(17-22)27(31)24-15-23(10-11-28-24)33-13-12-30/h4-11,14-15,22,30H,3,12-13,16-18H2,1-2H3
InChIKey
KVXLTGRHKNTTMZ-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of c-Fms-IN-8
CAS: 1255303-58-2
CID: 59634061
Formula: C27H30N2O5
MW: 462.5
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight462.5
XLogP33.7
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count6
Rotatable Bond Count10
Exact Mass462.21547206
Monoisotopic Mass462.21547206
Topological Polar Surface Area81.1 Ų
Heavy Atom Count34
Formal Charge0
Complexity620
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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BA8857-1c-Fms-IN-8
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