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FTI 276

CAT: 0013-GTR19205843-02Size: 50 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19205843-02Size:50 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
FTI-276 is a potent and selective inhibitor of protein farnesyltransferase (PFT), demonstrating high activity against both Plasmodium falciparum and human enzymes. This compound is a valuable research tool for studying farnesylation in cancer biology and parasitology, with applications in both in vitro enzymatic assays and cellular mechanism studies.
CAS Number
170006-72-1
Field of Research
Metabolism Research
Smiles
C (N[C@@H] (CCSC) C (O) =O) (=O) C1=C (C=C (NC[C@H] (CS) N) C=C1) C2=CC=CC=C2
Molecular Formula
C21H27N3O3S2
Molecular Weight
433.59
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

Fti 276

(2S)-2-[[[4-[[(2R)-2-amino-3-mercaptopropyl]amino]-2-phenylphenyl]-oxomethyl]amino]-4-(methylthio)butanoic acid is a methionine derivative.

CAS Number170006-72-1
PubChem CID395754
IUPAC Name(2S)-2-[[4-[[(2R)-2-amino-3-sulfanylpropyl]amino]-2-phenylbenzoyl]amino]-4-methylsulfanylbutanoic acid
Molecular FormulaC21H27N3O3S2
Molecular Weight433.6
XLogP0.6
Topological Polar Surface Area131
Hydrogen Bond Donor Count5
Hydrogen Bond Acceptor Count7
Rotatable Bond Count11
Heavy Atom Count29
Formal Charge0
Complexity517
SMILES
CSCC[C@@H](C(=O)O)NC(=O)C1=C(C=C(C=C1)NC[C@H](CS)N)C2=CC=CC=C2
InChI
InChI=1S/C21H27N3O3S2/c1-29-10-9-19(21(26)27)24-20(25)17-8-7-16(23-12-15(22)13-28)11-18(17)14-5-3-2-4-6-14/h2-8,11,15,19,23,28H,9-10,12-13,22H2,1H3,(H,24,25)(H,26,27)/t15-,19+/m1/s1
InChIKey
ZIXDDEATQSBHHL-BEFAXECRSA-N
Chemical Structure
2D Structure
2D structure of Fti 276
CAS: 170006-72-1
CID: 395754
Formula: C21H27N3O3S2
MW: 433.6
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight433.6
XLogP30.6
Hydrogen Bond Donor Count5
Hydrogen Bond Acceptor Count7
Rotatable Bond Count11
Exact Mass433.14938408
Monoisotopic Mass433.14938408
Topological Polar Surface Area131 Ų
Heavy Atom Count29
Formal Charge0
Complexity517
Isotope Atom Count0
Defined Atom Stereocenter Count2
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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