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K-80003

CAT: 0013-GTR19206290-02Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19206290-02Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
K-80003 (TX-803) is a potent small molecule RXRα regulator that suppresses tumor cell proliferation by inhibiting TRxrα-mediated Akt activation. It is a valuable research tool for studying oncogenic signaling pathways and has demonstrated anti-proliferative effects in various in vitro cancer cell models.
CAS Number
1292821-90-9
Product Name Alternative
Akt, K 80003, K80003, K-80003, TX 803, TX803, TX-803, retinoid X receptor α, RXR, RAR
Field of Research
Metabolism Research, Signal Transduction
Purity
99.45% (May vary between batches)
Solubility
10% DMSO+40% PEG300+5% Tween 80+45% Saline:2.5 mg/mL (7.43 mM) ; DMSO:60 mg/mL (178.36 mM)
Smiles
CC (C) c1ccc (\C=C2\C (C) =C (CC (O) =O) c3cc (F) ccc23) cc1
Molecular Formula
C22H21FO2
Molecular Weight
336.4
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

K-80003

[5-fluoro-1-(4-isopropylbenzylidene)-2-methylinden-3-yl]acetic acid is a sulindac-based non-steroidal anti-inflammatory drug. It has a role as a non-steroidal anti-inflammatory drug. It is functionally related to an acetic acid.

CAS Number1292821-90-9
PubChem CID46224594
IUPAC Name2-[(3Z)-6-fluoro-2-methyl-3-[(4-propan-2-ylphenyl)methylidene]inden-1-yl]acetic acid
Molecular FormulaC22H21FO2
Molecular Weight336.4
XLogP5.4
Topological Polar Surface Area37.3
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count3
Rotatable Bond Count4
Heavy Atom Count25
Formal Charge0
Complexity567
SMILES
CC\1=C(C2=C(/C1=C\C3=CC=C(C=C3)C(C)C)C=CC(=C2)F)CC(=O)O
InChI
InChI=1S/C22H21FO2/c1-13(2)16-6-4-15(5-7-16)10-19-14(3)20(12-22(24)25)21-11-17(23)8-9-18(19)21/h4-11,13H,12H2,1-3H3,(H,24,25)/b19-10-
InChIKey
QCXBVGNDRYQVJO-GRSHGNNSSA-N
Chemical Structure
2D Structure
2D structure of K-80003
CAS: 1292821-90-9
CID: 46224594
Formula: C22H21FO2
MW: 336.4
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight336.4
XLogP35.4
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count3
Rotatable Bond Count4
Exact Mass336.15255807
Monoisotopic Mass336.15255807
Topological Polar Surface Area37.3 Ų
Heavy Atom Count25
Formal Charge0
Complexity567
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count1
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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