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LGD-6972

CAT: 0013-GTR19205537-03Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19205537-03Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
LGD-6972
CAS Number
1207989-09-0
Product Name Alternative
Inhibitor, inhibit, LGD6972, LGD-6972, LGD 6972, GCGR, hyperglycaemia, Glucagon Receptor, glucagon, GlucagonReceptor, glucagon receptor, cAMP, Diabetes
Field of Research
Pharmacology & Drug Discovery
Purity
98.80% (May vary between batches)
Solubility
DMSO:31 mg/mL (44.1 mM) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (2.85 mM)
Smiles
Cc1cc (C) c (c (C) c1) -c1ccc (NC (=O) [C@H] (Cc2ccc (cc2) C (=O) NCCS (O) (=O) =O) c2ccc (cc2) -c2ccc (cc2) C (C) (C) C) cc1
Molecular Formula
C43H46N2O5S
Molecular Weight
702.9
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

Lgd-6972

LGD-6972 is under investigation in clinical trial NCT01919684 (Study to Evaluate Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of LGD-6972 in Healthy Subjects and Subjects With Type 2 Diabetes Mellitus).

CAS Number1207989-09-0
PubChem CID44625560
IUPAC Name2-[[4-[(2R)-2-[4-(4-tert-butylphenyl)phenyl]-3-oxo-3-[4-(2,4,6-trimethylphenyl)anilino]propyl]benzoyl]amino]ethanesulfonic acid
Molecular FormulaC43H46N2O5S
Molecular Weight702.9
XLogP8.9
Topological Polar Surface Area121
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count5
Rotatable Bond Count12
Heavy Atom Count51
Formal Charge0
Complexity1200
SMILES
CC1=CC(=C(C(=C1)C)C2=CC=C(C=C2)NC(=O)[C@H](CC3=CC=C(C=C3)C(=O)NCCS(=O)(=O)O)C4=CC=C(C=C4)C5=CC=C(C=C5)C(C)(C)C)C
InChI
InChI=1S/C43H46N2O5S/c1-28-25-29(2)40(30(3)26-28)35-17-21-38(22-18-35)45-42(47)39(27-31-7-9-36(10-8-31)41(46)44-23-24-51(48,49)50)34-13-11-32(12-14-34)33-15-19-37(20-16-33)43(4,5)6/h7-22,25-26,39H,23-24,27H2,1-6H3,(H,44,46)(H,45,47)(H,48,49,50)/t39-/m1/s1
InChIKey
HKJMCBYPVCGZFB-LDLOPFEMSA-N
Chemical Structure
2D Structure
2D structure of Lgd-6972
CAS: 1207989-09-0
CID: 44625560
Formula: C43H46N2O5S
MW: 702.9
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight702.9
XLogP38.9
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count5
Rotatable Bond Count12
Exact Mass702.31274375
Monoisotopic Mass702.31274375
Topological Polar Surface Area121 Ų
Heavy Atom Count51
Formal Charge0
Complexity1200
Isotope Atom Count0
Defined Atom Stereocenter Count1
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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