Ramelteon-d5

Ramelteon-d5

• CAS Number: 1134159-63-9
• UNSPSC Description: Ramelteon-d5 is deuterium labeled Ramelteon. Ramelteon is a potent, highly selective, and orally active agonist of MT1/MT2 with Ki values of 14 and 112 pM, respectively. Ramelteon has the potential for the research of insomnia. Ramelteon consistently reduces sleep onset after long-term treatment, with no next-morning residual effects or rebound insomnia or withdrawal symptoms upon discontinuation[1][2].
• Target Antigen: Isotope-Labeled Compounds; Melatonin Receptor
• Type: Isotope-Labeled Compounds
• Related Pathways: GPCR/G Protein;Neuronal Signaling;Others
• Applications: Metabolism-protein/nucleotide metabolism
• Field of Research: Neurological Disease; Endocrinology; Cancer
• Solubility: 10 mM in DMSO
• Smiles: [2H]C([2H])([2H])C([2H])([2H])C(NCC[C@H]1C2=C(CC1)C=CC3=C2CCO3)=O
• Molecular Weight: 264.37
• References & Citations: [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.|[2]Hirai K, et al. Ramelteon (TAK-375) accelerates reentrainment of circadian rhythm after a phase advance of the light-dark cycle in rats. J Biol Rhythms. 2005;20(1):27-37.|[3]Kato K, et al. Neurochemical properties of ramelteon (TAK-375), a selective MT1/MT2 receptor agonist. Neuropharmacology. 2005;48(2):301-310.|[4]Mayer G, et al. Efficacy and safety of 6-month nightly ramelteon administration in adults with chronic primary insomnia. Sleep. 2009;32(3):351-360. |[5]Miyamoto M, et al. The sleep-promoting action of ramelteon (TAK-375) in freely moving cats. Sleep. 2004;27(7):1319-1325.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported