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Ramelteon (Standard)

CAT: 0804-HY-A0014R-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-A0014R-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Ramelteon (Standard) is the analytical standard of Ramelteon. This product is intended for research and analytical applications. Ramelteon is a potent, highly selective, and orally active agonist of MT1/MT2 with Ki values of 14 and 112 pM, respectively. Ramelteon has the potential for the research of insomnia. Ramelteon consistently reduces sleep onset after long-term treatment, with no next-morning residual effects or rebound insomnia or withdrawal symptoms upon discontinuation[1][2].
CAS Number
196597-26-9
Product Name Alternative
TAK-375 (Standard)
UNSPSC
12352005
Hazard Statement
H302-H319-H332
Target
Melatonin Receptor; Reference Standards
Type
Reference Standards
Related Pathways
GPCR/G Protein; Neuronal Signaling; Others
Field of Research
Neurological Disease; Endocrinology; Cancer
Assay Protocol
https://www.medchemexpress.com/ramelteon-standard.html
Smiles
O=C(NCC[C@H]1C2=C(C=CC3=C2CCO3)CC1)CC
Molecular Formula
C16H21NO2
Molecular Weight
259.34
Precautions
P261-P264-P270-P271-P280-P304+P340-P305+P351+P338-P330-P501
References & Citations
[1]Kato K, et al. Neurochemical properties of ramelteon (TAK-375), a selective MT1/MT2 receptor agonist. Neuropharmacology. 2005;48 (2) :301-310.|[2]Mayer G, et al. Efficacy and safety of 6-month nightly ramelteon administration in adults with chronic primary insomnia. Sleep. 2009;32 (3) :351-360. |[3]Hirai K, et al. Ramelteon (TAK-375) accelerates reentrainment of circadian rhythm after a phase advance of the light-dark cycle in rats. J Biol Rhythms. 2005;20 (1) :27-37.|[4]Miyamoto M, et al. The sleep-promoting action of ramelteon (TAK-375) in freely moving cats. Sleep. 2004;27 (7) :1319-1325.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards

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