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LY3154207

CAT: 0013-GTR19205488-02Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19205488-02Size:25 mg
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Description
LY3154207 is a potent, orally bioavailable, and highly selective positive allosteric modulator (PAM) of the human dopamine D1 receptor, exhibiting an EC50 of 3 nM with negligible intrinsic agonist activity. This compound is a valuable research tool for investigating D1 receptor function in neurological disorders, supporting both in vitro binding assays and in vivo behavioral studies.
CAS Number
1638667-79-4
Field of Research
Neuroscience, Pharmacology & Drug Discovery
Smiles
C[C@@H]1N ([C@@H] (CO) Cc2c (CCC (C) (C) O) cccc12) C (=O) Cc1c (Cl) cccc1Cl
Molecular Formula
C24H29Cl2NO3
Molecular Weight
450.4
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

Mevidalen

Mevidalen is under investigation in clinical trial NCT03305809 (A Study of LY3154207 in Participants With Dementia Due to Lewy Body Dementia (LBD) Associated With Idiopathic Parkinson's Disease (PD) or Dementia With Lewy Bodies (DLB)).

CAS Number1638667-79-4
PubChem CID86290953
IUPAC Name2-(2,6-dichlorophenyl)-1-[(1S,3R)-3-(hydroxymethyl)-5-(3-hydroxy-3-methylbutyl)-1-methyl-3,4-dihydro-1H-isoquinolin-2-yl]ethanone
Molecular FormulaC24H29Cl2NO3
Molecular Weight450.4
XLogP4.4
Topological Polar Surface Area60.8
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count3
Rotatable Bond Count6
Heavy Atom Count30
Formal Charge0
Complexity577
SMILES
C[C@H]1C2=CC=CC(=C2C[C@@H](N1C(=O)CC3=C(C=CC=C3Cl)Cl)CO)CCC(C)(C)O
InChI
InChI=1S/C24H29Cl2NO3/c1-15-18-7-4-6-16(10-11-24(2,3)30)19(18)12-17(14-28)27(15)23(29)13-20-21(25)8-5-9-22(20)26/h4-9,15,17,28,30H,10-14H2,1-3H3/t15-,17+/m0/s1
InChIKey
XHCSBQBBGNQINS-DOTOQJQBSA-N
Chemical Structure
2D Structure
2D structure of Mevidalen
CAS: 1638667-79-4
CID: 86290953
Formula: C24H29Cl2NO3
MW: 450.4
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight450.4
XLogP34.4
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count3
Rotatable Bond Count6
Exact Mass449.1524492
Monoisotopic Mass449.1524492
Topological Polar Surface Area60.8 Ų
Heavy Atom Count30
Formal Charge0
Complexity577
Isotope Atom Count0
Defined Atom Stereocenter Count2
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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