Products for Research Use Only
RegisterLogin

LY3154207

CAT: 0804-HY-128770-01Size: 5 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-128770-01Size:5 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
LY3154207 is a potent, subtype selective, and orally available human dopamine D1 receptor positive allosteric modulator (PAM) with minimal allosteric agonist activity (EC50=3 nM) [1].
CAS Number
1638667-79-4
UNSPSC
12352005
Hazard Statement
H302, H315, H319
Target
Dopamine Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/ly3154207.html
Concentration
10mM
Purity
98.06
Solubility
DMSO : 110 mg/mL (ultrasonic)
Smiles
O=C(N1[C@@H](C)C2=C(C(CCC(C)(O)C)=CC=C2)C[C@@H]1CO)CC3=C(Cl)C=CC=C3Cl
Molecular Formula
C24H29Cl2NO3
Molecular Weight
450.40
Precautions
H302, H315, H319
References & Citations
[1]Hao J, Synthesis and Pharmacological Characterization of 2- (2,6-Dichlorophenyl) -1- ((1S,3R) -5- (3-hydroxy-3-methylbutyl) -3- (hydroxymethyl) -1-methyl-3,4-dihydroisoquinolin-2 (1H) -yl) ethan-1-one (LY3154207), a Potent, Subtype Selective, and Orally Available Positive Allosteric Modulator of the Human Dopamine D1 Receptor. J Med Chem. 2019 Oct 10;62 (19) :8711-8732.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 2
Isoform
D1 Receptor

Related Products

CatalogName
HY-111116LY3104607

Alternative Products

CatalogName
T11912-01LY3154207

Popular Products