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UK-101

CAT: 0013-GTR19204560-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19204560-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
UK-101 is a potent, selective immunoproteasome inhibitor targeting the LMP2 (β1i) subunit with high affinity, inducing apoptosis in prostate cancer models. It is a valuable research tool for studying immunoproteasome function in oncogenesis and has been utilized in both in vitro and in vivo experimental studies of cancer cell death mechanisms.
CAS Number
1000313-40-5
Product Name Alternative
Immunoproteasome β1c, immunoproteasome β5, LMP2, UK101, UK-101, UK 101
Field of Research
Cell Biology, Protein Biochemistry
Purity
98.97% (May vary between batches)
Solubility
DMSO:237.5 mg/mL (489.95 mM) ;10% DMSO+90% Corn Oil:3.3 mg/mL (6.81 mM)
Smiles
C ([C@@H] (NC ([C@@H] (NC (CCCCCC) =O) C) =O) CC (C) C) (=O) [C@@]1 (CO[Si] (C (C) (C) C) (C) C) CO1
Molecular Formula
C25H48N2O5Si
Molecular Weight
484.74
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

CID 24752894
CAS Number1000313-40-5
PubChem CID24752894
IUPAC NameN-[(2S)-1-[[(2S)-1-[(2S)-2-[[tert-butyl(dimethyl)silyl]oxymethyl]oxiran-2-yl]-4-methyl-1-oxopentan-2-yl]amino]-1-oxopropan-2-yl]heptanamide
Molecular FormulaC25H48N2O5Si
Molecular Weight484.7
Topological Polar Surface Area97
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count5
Rotatable Bond Count16
Heavy Atom Count33
Formal Charge0
Complexity674
SMILES
CCCCCCC(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)[C@]1(CO1)CO[Si](C)(C)C(C)(C)C
InChI
InChI=1S/C25H48N2O5Si/c1-10-11-12-13-14-21(28)26-19(4)23(30)27-20(15-18(2)3)22(29)25(16-31-25)17-32-33(8,9)24(5,6)7/h18-20H,10-17H2,1-9H3,(H,26,28)(H,27,30)/t19-,20-,25-/m0/s1
InChIKey
OHYPIFPQEYUPDQ-RLSLOFABSA-N
Chemical Structure
2D Structure
2D structure of CID 24752894
CAS: 1000313-40-5
CID: 24752894
Formula: C25H48N2O5Si
MW: 484.7
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight484.7
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count5
Rotatable Bond Count16
Exact Mass484.33324917
Monoisotopic Mass484.33324917
Topological Polar Surface Area97 Ų
Heavy Atom Count33
Formal Charge0
Complexity674
Isotope Atom Count0
Defined Atom Stereocenter Count3
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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