Products for Research Use Only
RegisterLogin

Hsp90-Cdc37-IN-1

CAT: 0013-GTR19204314-01Size: 25 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0013-GTR19204314-01Size:25 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
Hsp90-Cdc37-IN-1 is a potent small molecule disruptor of the Hsp90-Cdc37 chaperone complex with an IC50 of 140 nM. Its mechanism enables the inhibition of cancer cell migration and the reversal of drug resistance in vitro, making it a valuable tool for oncology and molecular chaperone research.
CAS Number
2227303-22-0
Field of Research
Metabolism Research, Signal Transduction
Smiles
C[C@]12[C@@] ([C@]3 (C) [C@@] (CC1) (C (C) (C) [C@@H] (OC (CCC (NC=4SC=5C (N4) =CC=C (F) C5) =O) =O) CC3) [H]) (C (=O) C=C6[C@@]2 (C) CC[C@]7 (C) [C@]6 (C[C@] (C (OCC) =O) (C) CC7) [H]) [H]
Molecular Formula
C43H57FN2O6S
Molecular Weight
748.99
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

Hsp90-Cdc37-IN-1
CAS Number2227303-22-0
PubChem CID137628647
IUPAC Nameethyl (2S,4aS,6aR,6aS,6bR,8aR,10S,12aS,14bR)-10-[4-[(6-fluoro-1,3-benzothiazol-2-yl)amino]-4-oxobutanoyl]oxy-2,4a,6a,6b,9,9,12a-heptamethyl-13-oxo-3,4,5,6,6a,7,8,8a,10,11,12,14b-dodecahydro-1H-picene-2-carboxylate
Molecular FormulaC43H57FN2O6S
Molecular Weight749.0
XLogP9.3
Topological Polar Surface Area140
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count9
Rotatable Bond Count9
Heavy Atom Count53
Formal Charge0
Complexity1550
SMILES
CCOC(=O)[C@]1(CC[C@@]2(CC[C@@]3(C(=CC(=O)[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OC(=O)CCC(=O)NC6=NC7=C(S6)C=C(C=C7)F)C)C)[C@@H]2C1)C)C)C
InChI
InChI=1S/C43H57FN2O6S/c1-9-51-36(50)40(5)19-18-39(4)20-21-42(7)26(27(39)24-40)23-29(47)35-41(6)16-15-32(38(2,3)31(41)14-17-43(35,42)8)52-34(49)13-12-33(48)46-37-45-28-11-10-25(44)22-30(28)53-37/h10-11,22-23,27,31-32,35H,9,12-21,24H2,1-8H3,(H,45,46,48)/t27-,31-,32-,35+,39+,40-,41-,42+,43+/m0/s1
InChIKey
ZFBDNLXDWSUBHR-RTIJATDVSA-N
Chemical Structure
2D Structure
2D structure of Hsp90-Cdc37-IN-1
CAS: 2227303-22-0
CID: 137628647
Formula: C43H57FN2O6S
MW: 749.0
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight749.0
XLogP39.3
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count9
Rotatable Bond Count9
Exact Mass748.39213688
Monoisotopic Mass748.39213688
Topological Polar Surface Area140 Ų
Heavy Atom Count53
Formal Charge0
Complexity1550
Isotope Atom Count0
Defined Atom Stereocenter Count9
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Related Products

CatalogName
GTR19263220-01Hsp90-Cdc37-IN-4
GTR18989607-01Human Hsp90 co-chaperone Cdc37 Protein
GTR19258377-01HSP90α-IN-1
GTR19264144-01Hsp90β-IN-1
GTR19249238-01CYP51/Hsp90-IN-1
GTR19186302-01Aha1/Hsp90-IN-1
GTR19185116-01HDAC6/HSP90-IN-1
GTR19213412-01HSP90/mTOR-IN-1
GTR17954509HSP90-1 Antibody
GTR19238636-01HSP90/LSD1-IN-1

Alternative Products

CatalogName
BA4199-25Hsp90-Cdc37-IN-1
A20095-50Hsp90-Cdc37-IN-1 50mg
A20095-25Hsp90-Cdc37-IN-1 25mg
A20095-100Hsp90-Cdc37-IN-1 100mg
A20095-5Hsp90-Cdc37-IN-1 5mg
A20095-1Hsp90-Cdc37-IN-1 1mg
A20095-10Hsp90-Cdc37-IN-1 10mg
BA3197-10Hsp90-Cdc37-IN-3
HY-130624-01Hsp90-Cdc37-IN-2
HY-174347Hsp90-Cdc37-IN-4

Popular Products