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AZD7687

CAT: 0013-GTR19203983-01Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19203983-01Size:25 mg
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Description
AZD7687 is a potent and selective DGAT1 inhibitor (IC50 = 80 nM) that reduces postprandial triglycerides in vivo. Its research applications include studying lipid metabolism and incretin hormone secretion (GLP-1, PYY), though clinical studies reported dose-limiting gastrointestinal side effects like diarrhea.
CAS Number
1166827-44-6
Field of Research
Metabolism Research
Smiles
Cc1nc (C) c (nc1C (N) =O) -c1ccc (cc1) [C@H]1CC[C@H] (CC (O) =O) CC1
Molecular Formula
C21H25N3O3
Molecular Weight
367.44
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

{4-[4-(6-Carbamoyl-3,5-dimethylpyrazin-2-yl)phenyl]cyclohexyl}acetic acid

AZD-7687 is under investigation in clinical trial NCT01119352 (AZD7687 Multiple Ascending Dose Study).

CAS Number1166827-44-6
PubChem CID42636350
IUPAC Name2-[4-[4-(6-carbamoyl-3,5-dimethylpyrazin-2-yl)phenyl]cyclohexyl]acetic acid
Molecular FormulaC21H25N3O3
Molecular Weight367.4
XLogP3.2
Topological Polar Surface Area106
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count5
Rotatable Bond Count5
Heavy Atom Count27
Formal Charge0
Complexity525
SMILES
CC1=C(N=C(C(=N1)C)C(=O)N)C2=CC=C(C=C2)C3CCC(CC3)CC(=O)O
InChI
InChI=1S/C21H25N3O3/c1-12-19(24-20(21(22)27)13(2)23-12)17-9-7-16(8-10-17)15-5-3-14(4-6-15)11-18(25)26/h7-10,14-15H,3-6,11H2,1-2H3,(H2,22,27)(H,25,26)
InChIKey
YXFNPRHZMOGREC-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of {4-[4-(6-Carbamoyl-3,5-dimethylpyrazin-2-yl)phenyl]cyclohexyl}acetic acid
CAS: 1166827-44-6
CID: 42636350
Formula: C21H25N3O3
MW: 367.4
Interactive 3D Structure
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View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight367.4
XLogP33.2
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count5
Rotatable Bond Count5
Exact Mass367.18959167
Monoisotopic Mass367.18959167
Topological Polar Surface Area106 Ų
Heavy Atom Count27
Formal Charge0
Complexity525
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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