Products for Research Use Only
RegisterLogin

KIRA-7

CAT: 0013-GTR19203706-02Size: 50 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0013-GTR19203706-02Size:50 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
KIRA-7 is an imidazopyrazine small molecule that acts as an allosteric inhibitor of IRE1α RNase activity by binding its kinase domain (IC50: 110 nM) . It exhibits anti-fibrotic properties and is utilized in research exploring endoplasmic reticulum stress in models of fibrotic disease, both in vitro and in vivo.
CAS Number
1937235-76-1
Field of Research
Cell Biology
Smiles
CC1 (CC1) c1nc (-c2ccc (NC (=O) Nc3cccc (F) c3) c3ccccc23) c2c (N) nccn12
Molecular Formula
C27H23FN6O
Molecular Weight
466.51
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

CID 121596794
CAS Number1937235-76-1
PubChem CID121596794
IUPAC Name1-[4-[8-amino-3-(1-methylcyclopropyl)imidazo[1,5-a]pyrazin-1-yl]naphthalen-1-yl]-3-(3-fluorophenyl)urea
Molecular FormulaC27H23FN6O
Molecular Weight466.5
XLogP5.1
Topological Polar Surface Area97.3
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count5
Rotatable Bond Count4
Heavy Atom Count35
Formal Charge0
Complexity779
SMILES
CC1(CC1)C2=NC(=C3N2C=CN=C3N)C4=CC=C(C5=CC=CC=C54)NC(=O)NC6=CC(=CC=C6)F
InChI
InChI=1S/C27H23FN6O/c1-27(11-12-27)25-33-22(23-24(29)30-13-14-34(23)25)20-9-10-21(19-8-3-2-7-18(19)20)32-26(35)31-17-6-4-5-16(28)15-17/h2-10,13-15H,11-12H2,1H3,(H2,29,30)(H2,31,32,35)
InChIKey
BMEJPYIGRYVVEF-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of CID 121596794
CAS: 1937235-76-1
CID: 121596794
Formula: C27H23FN6O
MW: 466.5
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight466.5
XLogP35.1
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count5
Rotatable Bond Count4
Exact Mass466.19173754
Monoisotopic Mass466.19173754
Topological Polar Surface Area97.3 Ų
Heavy Atom Count35
Formal Charge0
Complexity779
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Related Products

CatalogName
GTR191524297.7 MAG
GTR180271057.7 Antibody
GTR19215078-017-Deaza-7-iodoguanosine
GTR192541927-OXIDE-7-AZAINDOLE
GTR19164898-017-Cyano-7-deazaguanine
GTR19215343-017-Cyano-7-deazaguanosine
GTR19236271-01JWZ-7-7-Neg1
GTR19179790-017,7'-Dihydrotaiwanin C
GTR19230844-01Aβ-IN-7
GTR19191992-01AN-7

Alternative Products

CatalogName
HY-124646-01KIRA-7
X-LCP-1057.7 MAG
TBZ12367,7α-Diepialexine
sc-390856Dok-7 (A-7)
sc-398919Siglec-7 (A-7)
MBS71619887.7 Antibody
H998456Heptanoic-7,7,7-d3 Acid
B6838921-Bromoheptane-7,7,7-d3
168296IL-7 (IL7, IL-7 Interleukin 7, Interleukin-7)
C 214-057- Cyano- 7- deazainosine (7-CN-7-C-Ino / Jaspamycin)

Popular Products