Lometrexol

CAT: 0013-GTR19203597-02Size: 5 mgDry Ice: NoHazardous: No

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CAT#:0013-GTR19203597-02Size:5 mg

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Description

Lometrexol (LY 264618) is an antipurine antifolate that potently inhibits glycinamide ribonucleotide formyltransferase (GARFT) and human serine hydroxymethyltransferase (hSHMT1/2), disrupting de novo purine synthesis. This activity leads to suppressed cell proliferation, cell cycle arrest, and apoptosis, underpinning its research use as an anticancer agent in both in vitro and in vivo studies.

CAS Number

106400-81-1

Product Name Alternative

LY264618, LY-264618, LY 264618, Lometrexol, GARFT, DDATHF, Antifolate

Field of Research

Cell Biology, Metabolism Research, Molecular Biology, Protein Biochemistry

Purity

97.76% (May vary between batches)

Solubility

5% DMSO+40% PEG300+5% Tween 80+50% Saline:5 mg/mL (11.28 mM) ; DMSO:100 mg/mL (225.5 mM)

Smiles

Nc1nc2NC[C@H] (CCc3ccc (cc3) C (=O) N[C@@H] (CCC (O) =O) C (O) =O) Cc2c (=O) [nH]1

Molecular Formula

C21H25N5O6

Molecular Weight

443.45

Storage Conditions

-20°C

Notes

For research use only.

Chemical Information

Lometrexol

Lometrexol has been used in trials studying the treatment of Lung Cancer, Drug/Agent Toxicity by Tissue/Organ, and Unspecified Adult Solid Tumor, Protocol Specific.

CAS Number	106400-81-1
PubChem CID	135413518
IUPAC Name	(2S)-2-[[4-[2-[(6R)-2-amino-4-oxo-5,6,7,8-tetrahydro-3H-pyrido[2,3-d]pyrimidin-6-yl]ethyl]benzoyl]amino]pentanedioic acid
Molecular Formula	C21H25N5O6
Molecular Weight	443.5
XLogP	0.3
Topological Polar Surface Area	183
Hydrogen Bond Donor Count	6
Hydrogen Bond Acceptor Count	8
Rotatable Bond Count	9
Heavy Atom Count	32
Formal Charge	0
Complexity	831

SMILES

C1[C@H](CNC2=C1C(=O)NC(=N2)N)CCC3=CC=C(C=C3)C(=O)N[C@@H](CCC(=O)O)C(=O)O

InChI

InChI=1S/C21H25N5O6/c22-21-25-17-14(19(30)26-21)9-12(10-23-17)2-1-11-3-5-13(6-4-11)18(29)24-15(20(31)32)7-8-16(27)28/h3-6,12,15H,1-2,7-10H2,(H,24,29)(H,27,28)(H,31,32)(H4,22,23,25,26,30)/t12-,15+/m1/s1

InChIKey

ZUQBAQVRAURMCL-DOMZBBRYSA-N

Chemical Structure

2D Structure

CAS: 106400-81-1

CID: 135413518

Formula: C21H25N5O6

MW: 443.5

Interactive 3D Structure

Loading 3D structure...

View on PubChem Raw 3D data

Computed Properties

Property	Value
Molecular Weight	443.5
XLogP3	0.3
Hydrogen Bond Donor Count	6
Hydrogen Bond Acceptor Count	8
Rotatable Bond Count	9
Exact Mass	443.18048353
Monoisotopic Mass	443.18048353
Topological Polar Surface Area	183 Å²
Heavy Atom Count	32
Formal Charge	0
Complexity	831
Isotope Atom Count	0
Defined Atom Stereocenter Count	2
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Compound Is Canonicalized	Yes

Alternative Products

Catalog	Name
E1766-1mg	Lometrexol
HY-14521A-01	Lometrexol (disodium)
MBS5805914	Lometrexol disodium
HY-14521B-01	Lometrexol (hydrate)
TRC-L469465-5MG	Lometrexol Hydrate
A15980-5	Lometrexol disodium 5mg
A15980-25	Lometrexol disodium 25mg
A15980-10	Lometrexol disodium 10mg
597221	Lometrexol free acid
A15980-50	Lometrexol disodium 50mg

Lometrexol

Chemical Information

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