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Oglemilast

CAT: 0013-GTR19203591-01Size: 2 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19203591-01Size:2 mg
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Description
Oglemilast (GRC 3886) is a potent and orally bioavailable PDE4 inhibitor, with an IC50 of 0.5 nM for PDE4D3. It reduces pulmonary eosinophil and neutrophil infiltration in experimental models, supporting its research application for inflammatory airway diseases like asthma and COPD.
CAS Number
778576-62-8
Product Name Alternative
PDE4D3, PDE4D, Oglemilast, GRC-3886, GRC 3886, GRC3886
Field of Research
Metabolism Research
Purity
98.11% (May vary between batches)
Solubility
DMSO:3.6 mg/mL (6.97 mM)
Smiles
CS (=O) (=O) Nc1ccc2oc3c (OC (F) F) ccc (C (=O) Nc4c (Cl) cncc4Cl) c3c2c1
Molecular Formula
C20H13Cl2F2N3O5S
Molecular Weight
516.3
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

Oglemilast

Oglemilast has been investigated for the treatment of Pulmonary Disease, Chronic Obstructive.

CAS Number778576-62-8
PubChem CID11387409
IUPAC NameN-(3,5-dichloro-4-pyridinyl)-4-(difluoromethoxy)-8-(methanesulfonamido)dibenzofuran-1-carboxamide
Molecular FormulaC20H13Cl2F2N3O5S
Molecular Weight516.3
XLogP4.6
Topological Polar Surface Area119
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count9
Rotatable Bond Count6
Heavy Atom Count33
Formal Charge0
Complexity810
SMILES
CS(=O)(=O)NC1=CC2=C(C=C1)OC3=C(C=CC(=C23)C(=O)NC4=C(C=NC=C4Cl)Cl)OC(F)F
InChI
InChI=1S/C20H13Cl2F2N3O5S/c1-33(29,30)27-9-2-4-14-11(6-9)16-10(3-5-15(18(16)31-14)32-20(23)24)19(28)26-17-12(21)7-25-8-13(17)22/h2-8,20,27H,1H3,(H,25,26,28)
InChIKey
OKFDRAHPFKMAJH-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Oglemilast
CAS: 778576-62-8
CID: 11387409
Formula: C20H13Cl2F2N3O5S
MW: 516.3
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight516.3
XLogP34.6
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count9
Rotatable Bond Count6
Exact Mass514.9921034
Monoisotopic Mass514.9921034
Topological Polar Surface Area119 Ų
Heavy Atom Count33
Formal Charge0
Complexity810
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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A15197-10Oglemilast 10mg
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A15197-50Oglemilast 50mg
A15197-5Oglemilast 5mg

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