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SB228357

CAT: 0013-GTR19203117-02Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19203117-02Size:5 mg
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Description
SB228357 is a potent and selective 5-HT receptor antagonist, exhibiting pKi values of 6.9, 8.0, and 9.0 for the 5-HT2A, 5-HT2B, and 5-HT2C subtypes, respectively. This compound is a valuable research tool for investigating serotonergic signaling in both in vitro and in vivo models relevant to neuropharmacology and central nervous system disorders.
CAS Number
181629-93-6
Product Name Alternative
SB228357, SB-228357, SB 228357, 5HTReceptor, 5-HT2B Receptor, 5-HT2C, 5-HT2B, 5-HT2C Receptor, 5-HT2A, 5-HT2A Receptor, 5HT Receptor
Field of Research
Neuroscience, Pharmacology & Drug Discovery
Purity
99.31% (May vary between batches)
Solubility
DMSO:38.9 mg/mL (90.18 mM)
Smiles
COc1cc2CCN (C (=O) Nc3cc (F) cc (c3) -c3cccnc3) c2cc1C (F) (F) F
Molecular Formula
C22H17F4N3O2
Molecular Weight
431.38
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

SB 228357

SB 228357 is an indolyl carboxylic acid.

CAS Number181629-93-6
PubChem CID443390
IUPAC NameN-(3-fluoro-5-pyridin-3-ylphenyl)-5-methoxy-6-(trifluoromethyl)-2,3-dihydroindole-1-carboxamide
Molecular FormulaC22H17F4N3O2
Molecular Weight431.4
XLogP4.2
Topological Polar Surface Area54.5
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count7
Rotatable Bond Count3
Heavy Atom Count31
Formal Charge0
Complexity634
SMILES
COC1=C(C=C2C(=C1)CCN2C(=O)NC3=CC(=CC(=C3)C4=CN=CC=C4)F)C(F)(F)F
InChI
InChI=1S/C22H17F4N3O2/c1-31-20-9-13-4-6-29(19(13)11-18(20)22(24,25)26)21(30)28-17-8-15(7-16(23)10-17)14-3-2-5-27-12-14/h2-3,5,7-12H,4,6H2,1H3,(H,28,30)
InChIKey
RRJLJKRFFRZRAF-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of SB 228357
CAS: 181629-93-6
CID: 443390
Formula: C22H17F4N3O2
MW: 431.4
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight431.4
XLogP34.2
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count7
Rotatable Bond Count3
Exact Mass431.12568944
Monoisotopic Mass431.12568944
Topological Polar Surface Area54.5 Ų
Heavy Atom Count31
Formal Charge0
Complexity634
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
HY-103154-01SB228357

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