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Imipramine

CAT: 0013-GTR19202488-06Size: 500 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19202488-06Size:500 mg
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Description
Imipramine is an orally active Fascin1 inhibitor with antidepressant properties that also exhibits antitumor activity. It functions as a potent serotonin transporter blocker (IC50: 32 nM) and induces apoptosis and autophagy in glioma cells. Its neuroprotective and immunomodulatory effects, including inhibition of tumor cell invasion, make it a valuable research tool for studying cancers like glioblastoma and breast cancer, as well as neurological disorders.
CAS Number
50-49-7
Product Name Alternative
HSDB 3100, HSDB3100, HSDB-3100, Melipramine, fascin 1, Imipramine, Dimipressin, Apoptosis
Field of Research
Cell Biology, Neuroscience, Pharmacology & Drug Discovery
Purity
99.40% (May vary between batches)
Solubility
10% DMSO+40% PEG300+5% Tween-80+45% Saline:5 mg/mL (17.83 mM) ; DMSO:100 mg/mL (356.62 mM)
Smiles
C=1C=CC2=C (C1) N (C=3C=CC=CC3CC2) CCCN (C) C
Molecular Formula
C19H24N2
Molecular Weight
280.41
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

Imipramine

Imipramine is a dibenzoazepine that is 5H-dibenzo[b,f]azepine substituted by a 3-(dimethylamino)propyl group at the nitrogen atom. It has a role as an antidepressant, an adrenergic uptake inhibitor and an EC 3.4.21.26 (prolyl oligopeptidase) inhibitor. It derives from a hydride of a 5H-dibenzo[b,f]azepine.

CAS Number50-49-7
PubChem CID3696
IUPAC Name3-(5,6-dihydrobenzo[b][1]benzazepin-11-yl)-N,N-dimethylpropan-1-amine
Molecular FormulaC19H24N2
Molecular Weight280.4
XLogP4.8
Topological Polar Surface Area6.5
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count2
Rotatable Bond Count4
Heavy Atom Count21
Formal Charge0
Complexity291
SMILES
CN(C)CCCN1C2=CC=CC=C2CCC3=CC=CC=C31
InChI
InChI=1S/C19H24N2/c1-20(2)14-7-15-21-18-10-5-3-8-16(18)12-13-17-9-4-6-11-19(17)21/h3-6,8-11H,7,12-15H2,1-2H3
InChIKey
BCGWQEUPMDMJNV-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Imipramine
CAS: 50-49-7
CID: 3696
Formula: C19H24N2
MW: 280.4
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight280.4
XLogP34.8
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count2
Rotatable Bond Count4
Exact Mass280.193948774
Monoisotopic Mass280.193948774
Topological Polar Surface Area6.5 Ų
Heavy Atom Count21
Formal Charge0
Complexity291
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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