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TG-46

CAT: 0013-GTR19202106-05Size: 50 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19202106-05Size:50 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
TG-46 is a multi-kinase inhibitor targeting JAK2, FLT3, RET, and JAK3. It is a research tool for investigating glaucoma and has been utilized in both in vitro and in vivo studies to explore its therapeutic potential in related disease models.
CAS Number
936091-15-5
Product Name Alternative
FLT3, JAK2, JAK3, TG46, TG-46, TG 46
Field of Research
Cardiovascular Research, Epigenetics & Chromatin, Signal Transduction, Stem Cell & Developmental Biology
Purity
98.82% (May vary between batches)
Solubility
DMSO:45 mg/mL (88.12 mM)
Smiles
Cc1cnc (Nc2ccc (CN3CCOCC3) cc2) nc1Nc1cccc (c1) S (=O) (=O) NC (C) (C) C
Molecular Formula
C26H34N6O3S
Molecular Weight
510.65
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

N-(tert-butyl)-3-((5-methyl-2-((4-(morpholinomethyl)phenyl)amino)pyrimidin-4-yl)amino)benzenesulfonamide
CAS Number936091-15-5
PubChem CID16722834
IUPAC NameN-tert-butyl-3-[[5-methyl-2-[4-(morpholin-4-ylmethyl)anilino]pyrimidin-4-yl]amino]benzenesulfonamide
Molecular FormulaC26H34N6O3S
Molecular Weight510.7
XLogP3.7
Topological Polar Surface Area117
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count9
Rotatable Bond Count9
Heavy Atom Count36
Formal Charge0
Complexity772
SMILES
CC1=CN=C(N=C1NC2=CC(=CC=C2)S(=O)(=O)NC(C)(C)C)NC3=CC=C(C=C3)CN4CCOCC4
InChI
InChI=1S/C26H34N6O3S/c1-19-17-27-25(29-21-10-8-20(9-11-21)18-32-12-14-35-15-13-32)30-24(19)28-22-6-5-7-23(16-22)36(33,34)31-26(2,3)4/h5-11,16-17,31H,12-15,18H2,1-4H3,(H2,27,28,29,30)
InChIKey
MMXZBJJTHQWMEN-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of N-(tert-butyl)-3-((5-methyl-2-((4-(morpholinomethyl)phenyl)amino)pyrimidin-4-yl)amino)benzenesulfonamide
CAS: 936091-15-5
CID: 16722834
Formula: C26H34N6O3S
MW: 510.7
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight510.7
XLogP33.7
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count9
Rotatable Bond Count9
Exact Mass510.24131014
Monoisotopic Mass510.24131014
Topological Polar Surface Area117 Ų
Heavy Atom Count36
Formal Charge0
Complexity772
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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