MG-115

CAT: 0013-GTR19201670-06Size: 100 mgDry Ice: NoHazardous: No

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CAT#:0013-GTR19201670-06Size:100 mg

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Description

MG-115 (Z-LL-Nva-CHO) is a potent, reversible proteasome inhibitor that selectively targets the chymotrypsin-like activity, with K i values of 21 nM and 35 nM for the 20S and 26S proteasome, respectively. This compound is widely used in cancer research to study proteasome function, p53-dependent apoptosis, and cellular mechanisms in both in vitro and in vivo models.

CAS Number

133407-86-0

Product Name Alternative

MG 115, MG115, MG-115, 26S proteasome, 20S proteasome, Z-LL-Nva-CHO

Field of Research

Cell Biology, Protein Biochemistry

Purity

97.10% (May vary between batches)

Solubility

10% DMSO+90% Corn Oil:4 mg/mL (8.67 mM) ; DMSO:45 mg/mL (97.49 mM)

Smiles

CCCC (NC (=O) C (CC (C) C) NC (=O) C (CC (C) C) NC (=O) OCc1ccccc1) C=O

Molecular Formula

C25H39N3O5

Molecular Weight

461.59

Storage Conditions

-20°C

Notes

For research use only.

Chemical Information

MG-115

N-[(2S)-4-methyl-1-[[(2S)-4-methyl-1-oxo-1-[[(2S)-1-oxopentan-2-yl]amino]pentan-2-yl]amino]-1-oxopentan-2-yl]carbamic acid (phenylmethyl) ester is a peptide.

CAS Number	133407-86-0
PubChem CID	9868928
IUPAC Name	benzyl N-[(2S)-4-methyl-1-[[(2S)-4-methyl-1-oxo-1-[[(2S)-1-oxopentan-2-yl]amino]pentan-2-yl]amino]-1-oxopentan-2-yl]carbamate
Molecular Formula	C25H39N3O5
Molecular Weight	461.6
XLogP	4.4
Topological Polar Surface Area	114
Hydrogen Bond Donor Count	3
Hydrogen Bond Acceptor Count	5
Rotatable Bond Count	15
Heavy Atom Count	33
Formal Charge	0
Complexity	617

SMILES

CCC[C@@H](C=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)OCC1=CC=CC=C1

InChI

InChI=1S/C25H39N3O5/c1-6-10-20(15-29)26-23(30)21(13-17(2)3)27-24(31)22(14-18(4)5)28-25(32)33-16-19-11-8-7-9-12-19/h7-9,11-12,15,17-18,20-22H,6,10,13-14,16H2,1-5H3,(H,26,30)(H,27,31)(H,28,32)/t20-,21-,22-/m0/s1

InChIKey

QEJRGURBLQWEOU-FKBYEOEOSA-N

Chemical Structure

2D Structure

CAS: 133407-86-0

CID: 9868928

Formula: C25H39N3O5

MW: 461.6

Interactive 3D Structure

Loading 3D structure...

View on PubChem Raw 3D data

Computed Properties

Property	Value
Molecular Weight	461.6
XLogP3	4.4
Hydrogen Bond Donor Count	3
Hydrogen Bond Acceptor Count	5
Rotatable Bond Count	15
Exact Mass	461.28897135
Monoisotopic Mass	461.28897135
Topological Polar Surface Area	114 Å²
Heavy Atom Count	33
Formal Charge	0
Complexity	617
Isotope Atom Count	0
Defined Atom Stereocenter Count	3
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Compound Is Canonicalized	Yes

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456188-01	MG-115
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A11601-200	MG-115 200mg
A11601-50	MG-115 50mg
A11601-10	MG-115 10mg
A11601-1	MG-115 1mg
A11601-100	MG-115 100mg
A11601-25	MG-115 25mg
A11601-5	MG-115 5mg
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MG-115

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